Garcia-Dorival, Isabel 
ORCID: 0000-0002-5654-5662, Angel Cuesta-Geijo, Miguel, Barrado-Gil, Lucia, Galindo, Inmaculada, Garaigorta, Urtzi, Urquiza, Jesus, del Puerto, Ana, Campillo, Nuria E, Martinez, Ana, Gastaminza, Pablo et al (show 2 more authors)
(2021)
Identification of Niemann-Pick C1 protein as a potential novel SARS-CoV-2 intracellular target.
ANTIVIRAL RESEARCH, 194.
105167-.
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Identification of Niemann-Pick C1 protein as a potential novel SARS-CoV-2 intracellular target.pdf - Published version Download (3MB) | Preview |
Abstract
Niemann-Pick type C1 (NPC1) receptor is an endosomal membrane protein that regulates intracellular cholesterol traffic. This protein has been shown to play an important role for several viruses. It has been reported that SARS-CoV-2 enters the cell through plasma membrane fusion and/or endosomal entry upon availability of proteases. However, the whole process is not fully understood yet and additional viral/host factors might be required for viral fusion and subsequent viral replication. Here, we report a novel interaction between the SARS-CoV-2 nucleoprotein (N) and the cholesterol transporter NPC1. Furthermore, we have found that some compounds reported to interact with NPC1, carbazole SC816 and sulfides SC198 and SC073, were able to reduce SARS-CoV-2 viral infection with a good selectivity index in human cell infection models. These findings suggest the importance of NPC1 for SARS-CoV-2 viral infection and a new possible potential therapeutic target to fight against COVID-19.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | Niemann-pick type C1 (NPC1), SARS-CoV-2, SARS-CoV-2 nucleoprotein, Potential therapeutic target, Endosomes |
| Divisions: | Faculty of Health and Life Sciences Faculty of Health and Life Sciences > Institute of Infection, Veterinary and Ecological Sciences |
| Depositing User: | Symplectic Admin |
| Date Deposited: | 07 Feb 2022 14:53 |
| Last Modified: | 18 Jan 2023 21:13 |
| DOI: | 10.1016/j.antiviral.2021.105167 |
| Open Access URL: | https://doi.org/10.1016/j.antiviral.2021.105167 |
| Related URLs: | |
| URI: | https://livrepository.liverpool.ac.uk/id/eprint/3148429 |
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