de Clifford, Leigh Travis, Lowe, Jason Nicholas, McKellar, Campbell Duirs, McGowan, Catherine 
ORCID: 0000-0002-1946-9584 and David, Florent
(2021)
A Double-Blinded Positive Control Study Comparing the Relative Efficacy of 2.5% Polyacrylamide Hydrogel (PAAG) Against Triamcinolone Acetonide (TA) And Sodium Hyaluronate (HA) in the Management of Middle Carpal Joint Lameness in Racing Thoroughbreds.
Journal of equine veterinary science, 107.
p. 103780.
Abstract
The purpose of this prospective double-blinded positive control study was to compare the efficacy of 2.5% polyacrylamide hydrogel (2.5% PAAG) in the management of middle carpal joint lameness in Thoroughbreds against treatments of triamcinolone acetonide (TA) or sodium hyaluronate (HA). A total of 31 flat-racing Thoroughbreds with lameness (grade 1-3/5) localized to the carpus by intra-articular analgesia were selected. Following a radiological assessment of the carpi confirming the absence of fragment/fracture, the horses were randomly assigned for intra-articular treatment with either 2 ml of 2.5% PAAG, 12 mg TA or 20 mg HA (followed by two further intravenous treatments of 40 mg, at weekly intervals in the HA group only), by a treating veterinarian. All horses were rested for 48 hours post-treatment and then re-entered an unaltered training regimen. Subsequent examinations at 2, 4, and 6 weeks were performed by a blinded examining veterinarian for all groups, while horses treated with 2.5% PAAG were monitored for 12 weeks for recurrence of lameness. Significantly more joints treated with 2.5% PAAG were lame free (83%) at 6 weeks compared to TA (27%; P = .007) and to HA (40%; P = .04). There was no significant difference between TA and HA groups at any time. All the joints treated within 2.5% PAAG that were lame free at 6 weeks (10/12) were still lame-free at 12 weeks. In conclusion, treatment with 2.5% PAAG led to statistically superior results compared to TA and HA in the management of selected middle carpal joint lameness in flat-racing Thoroughbreds, with therapeutic effects persisting up to 12 weeks.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | Animals, Horses, Horse Diseases, Lameness, Animal, Triamcinolone Acetonide, Acrylic Resins, Hyaluronic Acid, Pregnancy-Associated alpha 2-Macroglobulins, Injections, Intra-Articular, Prospective Studies, Pregnancy, Female, Carpal Joints |
| Divisions: | Faculty of Health and Life Sciences Faculty of Health and Life Sciences > Institute of Infection, Veterinary and Ecological Sciences |
| Depositing User: | Symplectic Admin |
| Date Deposited: | 16 Feb 2022 09:47 |
| Last Modified: | 18 Jan 2023 21:12 |
| DOI: | 10.1016/j.jevs.2021.103780 |
| Open Access URL: | https://doi.org/10.1016/j.jevs.2021.103780 |
| Related URLs: | |
| URI: | https://livrepository.liverpool.ac.uk/id/eprint/3148987 |
Dimensions
Dimensions
