Pickering, Karen 
ORCID: 0000-0002-6903-8483 and Ireland, Joanne ORCID: 0000-0002-5737-1502
(2020)
Continuous digital hypothermia in the prevention and treatment of acute equine laminitis.
Veterinary Evidence, 5 (4).
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Abstract
<jats:p>PICO question
 Does continuous digital hypothermia improve clinical outcome in equids with acute laminitis compared to supportive treatment alone?
 
 Clinical bottom line
 Category of research question
 Treatment
 The number and type of study designs reviewed
 Six experimental randomised controlled trials and one multicentre retrospective case series were reviewed
 Strength of evidence
 Moderate
 Outcomes reported
 The outcomes reported were reduced severity of histopathological lamellar lesions in limbs treated with continuous digital hypothermia (CDH; initiated prior to or soon after the onset of experimentally induced acute laminitis) compared to limbs remaining at an ambient temperature in all five experimental studies where histology was performed. A significant reduction was observed in the prevalence or severity of clinical signs of laminitis in limbs treated with CDH compared to limbs remaining at an ambient temperature. In a single retrospective case series, significantly reduced prevalence of clinical laminitis was reported amongst animals receiving CDH compared to those that did not in a referral hospital population of animals treated for colitis
 Conclusion
 There is moderate evidence to support that CDH when used prior to or in the early stages of clinical signs, may reduce the severity and progression of lamellar lesions in acute laminitis and no evidence demonstrating that it improves clinical outcome compared to supportive treatment alone. Further research into the clinical outcome of equids treated for acute laminitis using CDH is warranted
 
 How to apply this evidence in practice
 The application of evidence into practice should take into account multiple factors, not limited to: individual clinical expertise, patient’s circumstances and owners’ values, country, location or clinic where you work, the individual case in front of you, the availability of therapies and resources.
 Knowledge Summaries are a resource to help reinforce or inform decision making. They do not override the responsibility or judgement of the practitioner to do what is best for the animal in their care.
 
 </jats:p>
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | Clinical Research, Digestive Diseases, Prevention |
| Divisions: | Faculty of Health and Life Sciences Faculty of Health and Life Sciences > Institute of Infection, Veterinary and Ecological Sciences |
| Depositing User: | Symplectic Admin |
| Date Deposited: | 17 Feb 2022 10:35 |
| Last Modified: | 14 Mar 2024 17:49 |
| DOI: | 10.18849/ve.v5i4.307 |
| Related URLs: | |
| URI: | https://livrepository.liverpool.ac.uk/id/eprint/3149109 |
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