Systems approaches to understand oxygen sensing: how multi-omics has driven advances in understanding oxygen-based signalling

Batie, M ORCID: 0000-0002-7508-6641, Kenneth, NS ORCID: 0000-0001-8528-1021 and Rocha, S (2022) Systems approaches to understand oxygen sensing: how multi-omics has driven advances in understanding oxygen-based signalling. The Biochemical journal, 479 (3). pp. 245-257.

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Official URL: http://dx.doi.org/10.1042/bcj20210554

Abstract

Hypoxia is a common denominator in the pathophysiology of a variety of human disease states. Insight into how cells detect, and respond to low oxygen is crucial to understanding the role of hypoxia in disease. Central to the hypoxic response is rapid changes in the expression of genes essential to carry out a wide range of functions to adapt the cell/tissue to decreased oxygen availability. These changes in gene expression are co-ordinated by specialised transcription factors, changes to chromatin architecture and intricate balances between protein synthesis and destruction that together establish changes to the cellular proteome. In this article, we will discuss the advances of our understanding of the cellular oxygen sensing machinery achieved through the application of 'omics-based experimental approaches.

Item Type:	Article
Uncontrolled Keywords:	Chromatin, Animals, Humans, Oxygen, Proteome, Transcription Factors, Signal Transduction, Cell Hypoxia, Gene Expression Regulation, Metabolome, Transcriptome
Divisions:	Faculty of Health and Life Sciences Faculty of Health and Life Sciences > Institute of Systems, Molecular and Integrative Biology
Depositing User:	Symplectic Admin
Date Deposited:	17 Feb 2022 10:30
Last Modified:	18 Jan 2023 21:12
DOI:	10.1042/BCJ20210554
Open Access URL:	https://portlandpress.com/biochemj/article/479/3/2...
Related URLs:	Author Publisher
URI:	https://livrepository.liverpool.ac.uk/id/eprint/3149111