Detection of <i>Trypanosoma vivax</i> in tissues of experimentally infected goats: what is the role of adipose tissue in the life cycle of this protozoon?


Machado, Rosangela Zacarias, de Almeida Castilho Neto, Kayo Jose Garcia, Goncalves, Luiz Ricardo, Machado, Gisele Fabrino, Rui Luvizotto, Maria Cecilia, Vasconcelos, Rosemeri de Oliveira, Jussiani, Giulia, Vieira da Silva, Thiago Merighi, Gimenes, Lindsay Unno, Jackson, Andrew ORCID: 0000-0002-5704-8596 et al (show 2 more authors) (2021) Detection of <i>Trypanosoma vivax</i> in tissues of experimentally infected goats: what is the role of adipose tissue in the life cycle of this protozoon? REVISTA BRASILEIRA DE PARASITOLOGIA VETERINARIA, 30 (4). e017721-.

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Abstract

Trypanosomiasis, caused by Trypanosoma vivax, is responsible for great economic losses among livestock in Africa and South America. During the life cycle of these parasites, they may present different morphological, metabolic and physiological characteristics depending on the interactions that are encountered at each point of their life cycle. Although T. vivax is frequently reported in the circulation of its mammalian hosts, it has the ability to migrate to the tissues of these individuals. However, this characteristic is poorly understood. In this context, we aimed to investigate the presence of T. vivax and the changes caused in different tissues of experimentally infected goats. Despite the animals were not perfused before tissues collection, using different approaches, we demonstrated its presence in different samples, including in the adipose tissue and skin of infected animals. In addition, a mononuclear inflammatory reaction, mostly characterized by an infiltrate of lymphocytes, plasma cells and macrophages were observed. The results highlight the possibility that, like other trypanosomatids, T. vivax may use these tissues during its life cycle. Future studies aiming to elucidate the length of time for which T. vivax remains active in these sites, and whether it uses these sites as a refuge from trypanocidal drugs, and whether it is capable of recolonizing the blood circulation, are much needed.

Item Type: Article
Uncontrolled Keywords: LAMP, livestock, refuge, trypanosomiasis, Trypanosoma vivax
Divisions: Faculty of Health and Life Sciences
Faculty of Health and Life Sciences > Institute of Infection, Veterinary and Ecological Sciences
Depositing User: Symplectic Admin
Date Deposited: 17 Feb 2022 16:10
Last Modified: 17 Oct 2023 19:33
DOI: 10.1590/S1984-29612021092
Related URLs:
URI: https://livrepository.liverpool.ac.uk/id/eprint/3149130
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