A prospective view of animal and human Fasciolosis.

Cwiklinski, K ORCID: 0000-0001-5577-2735, O'Neill, SM, Donnelly, S ORCID: 0000-0003-2005-3698 and Dalton, JP (2016) A prospective view of animal and human Fasciolosis. Parasite immunology, 38 (9). pp. 558-568.

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Official URL: http://dx.doi.org/10.1111/pim.12343

Abstract

Fasciolosis, a food-borne trematodiasis, results following infection with the parasites, Fasciola hepatica and Fasciola gigantica. These trematodes greatly affect the global agricultural community, infecting millions of ruminants worldwide and causing annual economic losses in excess of US $3 billion. Fasciolosis, an important zoonosis, is classified by WHO as a neglected tropical disease with an estimated 17 million people infected and a further 180 million people at risk of infection. The significant impact on agriculture and human health together with the increasing demand for animal-derived food products to support global population growth demonstrate that fasciolosis is a major One Health problem. This review details the problematic issues surrounding fasciolosis control, including drug resistance, lack of diagnosis and the threat that hybridization of the Fasciola species poses to future animal and human health. We discuss how these parasites may mediate their long-term survival through regulation and modulation of the host immune system, by altering the host immune homeostasis and/or by influencing the intestinal microbiome particularly in respect to concurrent infections with other pathogens. Large genome, transcriptome and proteomic data sets are now available to support an integrated One Health approach to develop novel diagnostic and control strategies for both animal and human disease.

Item Type:	Article
Uncontrolled Keywords:	Animals, Humans, Fasciola, Fasciola hepatica, Zoonoses, Fascioliasis, Proteomics
Divisions:	Faculty of Health and Life Sciences Faculty of Health and Life Sciences > Institute of Infection, Veterinary and Ecological Sciences
Depositing User:	Symplectic Admin
Date Deposited:	24 Feb 2022 09:01
Last Modified:	14 Mar 2024 17:46
DOI:	10.1111/pim.12343
Open Access URL:	https://onlinelibrary.wiley.com/doi/10.1111/pim.12...
Related URLs:	Author Publisher
URI:	https://livrepository.liverpool.ac.uk/id/eprint/3149586