Advances in Fasciola hepatica research using 'omics' technologies.

Cwiklinski, Krystyna ORCID: 0000-0001-5577-2735 and Dalton, John P ORCID: 0000-0003-3829-9186 (2018) Advances in Fasciola hepatica research using 'omics' technologies. International journal for parasitology, 48 (5). pp. 321-331.

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Official URL: http://dx.doi.org/10.1016/j.ijpara.2017.12.001

Abstract

The liver fluke Fasciola hepatica is an economically important pathogen of livestock worldwide, as well as being an important neglected zoonosis. Parasite control is reliant on the use of drugs, particularly triclabendazole, which is effective against multiple parasite stages. However, the spread of parasites resistant to triclabendazole has intensified the pursuit for novel control strategies. Emerging 'omics' technologies are helping advance our understanding of liver fluke biology, specifically the molecules that act at the host-parasite interface and are central to infection, virulence and long-term survival within the definitive host. This review discusses the technological sequencing advances that have facilitated the unbiased analysis of liver fluke biology, resulting in an extensive range of 'omics' datasets. In addition, we highlight the 'omics' studies of host responses to F. hepatica infection that, when combined with the parasite datasets, provide the opportunity for integrated analyses of host-parasite interactions. These extensive datasets will form the foundation for future in-depth analysis of F. hepatica biology and development, and the search for new drug or vaccine interventions.

Item Type:	Article
Uncontrolled Keywords:	Animals, Fasciola hepatica, Proteomics, Genomics, Gene Expression Regulation, Transcriptome
Divisions:	Faculty of Health and Life Sciences Faculty of Health and Life Sciences > Institute of Infection, Veterinary and Ecological Sciences
Depositing User:	Symplectic Admin
Date Deposited:	24 Feb 2022 09:02
Last Modified:	14 Mar 2024 17:46
DOI:	10.1016/j.ijpara.2017.12.001
Open Access URL:	https://pureadmin.qub.ac.uk/ws/portalfiles/portal/...
Related URLs:	Author Publisher
URI:	https://livrepository.liverpool.ac.uk/id/eprint/3149588