Inflammasome Contribution to the Activation of Th1, Th2, and Th17 Immune Responses

Martynova, Ekaterina, Rizvanov, Albert, Urbanowicz, Richard A ORCID: 0000-0002-2461-4993 and Khaiboullina, Svetlana (2022) Inflammasome Contribution to the Activation of Th1, Th2, and Th17 Immune Responses. Frontiers in Microbiology, 13. 851835-.

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Official URL: http://dx.doi.org/10.3389/fmicb.2022.851835

Abstract

<jats:p>Inflammasomes are cytosolic polyprotein complexes formed in response to various external and internal stimuli, including viral and bacterial antigens. The main product of the inflammasome is active caspase 1 which proteolytically cleaves, releasing functional interleukin-1 beta (IL-1β) and interleukin-18 (IL-18). These cytokines play a central role in shaping immune response to pathogens. In this review, we will focus on the mechanisms of inflammasome activation, as well as their role in development of Th1, Th2, and Th17 lymphocytes. The contribution of cytokines IL-1β, IL-18, and IL-33, products of activated inflammasomes, are summarized. Additionally, the role of cytokines released from tissue cells in promoting differentiation of lymphocyte populations is discussed.</jats:p>

Item Type:	Article
Uncontrolled Keywords:	inflammasome, Th1, Th2, Th17, immune response
Divisions:	Faculty of Health and Life Sciences Faculty of Health and Life Sciences > Institute of Infection, Veterinary and Ecological Sciences
Depositing User:	Symplectic Admin
Date Deposited:	23 Mar 2022 10:20
Last Modified:	18 Jan 2023 21:06
DOI:	10.3389/fmicb.2022.851835
Open Access URL:	https://www.frontiersin.org/articles/10.3389/fmicb...
Related URLs:	Author Publisher
URI:	https://livrepository.liverpool.ac.uk/id/eprint/3151343