Mahmud, Nur Musfirah, Paraoan, Luminita 
ORCID: 0000-0001-7568-7116, Khaliddin, Nurliza and Kamalden, Tengku Ain
(2022)
Thymoquinone in Ocular Neurodegeneration: Modulation of Pathological Mechanisms via Multiple Pathways.
FRONTIERS IN CELLULAR NEUROSCIENCE, 16.
786926-.
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Abstract
Thymoquinone is a naturally occurring compound and is the major component of <i>Nigella sativa</i>, also known as black seed or black cumin. For centuries thymoquinone has been used especially in the Middle East traditionally to treat wounds, asthma, allergies, fever, headache, cough, hypertension, and diabetes. Studies have suggested beneficial effects of thymoquinone to be attributed to its antioxidant, antibacterial, anti-oxidative stress, anti-inflammatory, and neuroprotective properties. Recently, there has been a surge of interest in thymoquinone as a treatment for neurodegeneration in the brain, such as that seen in Alzheimer's (AD) and Parkinson's diseases (PD). <i>In vitro</i> and <i>in vivo</i> studies on animal models of AD and PD suggest the main neuroprotective mechanisms are based on the anti-inflammatory and anti-oxidative properties of thymoquinone. Neurodegenerative conditions of the eye, such as Age-related Macular Degeneration (AMD) and glaucoma share at least in part similar mechanisms of neuronal cell death with those occurring in AD and PD. This review aims to summarize and critically analyze the evidence to date of the effects and potential neuroprotective actions of thymoquinone in the eye and ocular neurodegenerations.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | thymoquinone, neuroprotection, retinal pigment epithelium, oxidative stress, age-related macular degeneration |
| Divisions: | Faculty of Health and Life Sciences Faculty of Health and Life Sciences > Institute of Life Courses and Medical Sciences |
| Depositing User: | Symplectic Admin |
| Date Deposited: | 06 Apr 2022 13:19 |
| Last Modified: | 22 Mar 2023 09:59 |
| DOI: | 10.3389/fncel.2022.786926 |
| Related URLs: | |
| URI: | https://livrepository.liverpool.ac.uk/id/eprint/3152266 |
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