Buckley, Benjamin JR 
ORCID: 0000-0002-1479-8872, Harrison, Stephanie L ORCID: 0000-0002-8846-0946, Fazio-Eynullayeva, Elnara, Underhill, Paula, Lane, Deirdre A ORCID: 0000-0002-5604-9378, Thijssen, Dick HJ and Lip, Gregory YH ORCID: 0000-0002-7566-1626
(2022)
Exercise-Based Cardiac Rehabilitation Associates with Lower Major Adverse Cardiovascular Events in People with Stroke.
CEREBROVASCULAR DISEASES, 51 (4).
pp. 488-492.
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Exercise-based cardiac rehabilitation associates with lower major adverse cardiovascular events in people following a stroke .pdf - Author Accepted Manuscript Download (595kB) | Preview |
Abstract
<h4>Background</h4>The risk of major adverse cardiovascular events is substantially increased following a stroke. Although exercise-based cardiac rehabilitation has been shown to improve prognosis following cardiac events, it is not part of routine care for people following a stroke. We therefore investigated the association between cardiac rehabilitation and major adverse cardiovascular events for people with stroke.<h4>Methods</h4>This retrospective analysis was conducted on June 20, 2021, using anonymized data within TriNetX, a global federated health research network with access to electronic medical records from participating healthcare organizations, predominantly in the USA. All participants were aged ≥18 years with cerebrovascular disease and at least 2 years of follow-up. People with stroke and an electronic medical record of exercise-based cardiac rehabilitation were 1:1 propensity score matched to people with stroke but without cardiac rehabilitation using participant characteristics, comorbidities, cardiovascular procedures, and cardiovascular medications.<h4>Results</h4>Of 836,923 people with stroke and 2-year follow-up, 2,909 met the inclusion for the exercise-based cardiac rehabilitation cohort. Following propensity score matching (n = 5,818), exercise-based cardiac rehabilitation associated with 53% lower odds of all-cause mortality (odds ratio 0.47, 95% confidence interval: 0.40-0.56), 12% lower odds of recurrent stroke (0.88, 0.79-0.98), and 36% lower odds of rehospitalization (0.64, 0.58-0.71), compared to controls. No significant association between cardiac rehabilitation and incident atrial fibrillation was observed.<h4>Conclusion</h4>Exercise-based cardiac rehabilitation prescribed for people following a stroke associated with significantly lower odds of major adverse cardiovascular events at 2 years, compared to usual care.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | Exercise, Cardiac rehabilitation, Secondary prevention, Stroke, MACE, Preventive cardiology |
| Divisions: | Faculty of Health and Life Sciences Faculty of Health and Life Sciences > Institute of Life Courses and Medical Sciences |
| Depositing User: | Symplectic Admin |
| Date Deposited: | 11 Apr 2022 15:01 |
| Last Modified: | 26 Jan 2023 02:53 |
| DOI: | 10.1159/000521025 |
| Related URLs: | |
| URI: | https://livrepository.liverpool.ac.uk/id/eprint/3152705 |
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