Recent advances in understanding pancreatic cancer.

Stott, Martyn C ORCID: 0000-0002-3536-8281, Oldfield, Lucy ORCID: 0000-0002-0839-402X, Hale, Jessica, Costello, Eithne and Halloran, Christopher M ORCID: 0000-0002-5471-4178 (2022) Recent advances in understanding pancreatic cancer. Faculty reviews, 11. 9-.

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Abstract

Pancreatic ductal adenocarcinoma (PDAC) is an intractable cancer and a leading cause of cancer deaths worldwide. Over 90% of patients die within 1 year of diagnosis. Deaths from PDAC are increasing and it remains a cancer of substantial unmet need. A number of factors contribute to its poor prognosis: namely, late presentation, early metastases and limited systemic therapy options because of chemoresistance. A variety of research approaches underway are aimed at improving patient survival. Here, we review high-risk groups and efforts for early detection. We examine recent developments in the understanding of complex molecular and metabolic alterations which accompany PDAC. We explore artificial intelligence and biological targets for therapy and examine the role of tumour stroma and the immune microenvironment. We also review recent developments with respect to the PDAC microbiome. It is hoped that current research efforts will translate into earlier diagnosis, improvements in treatment and better outcomes for patients.

Item Type:	Article
Uncontrolled Keywords:	Pancreatic ductal adenocarcinoma (PDAC), artificial intelligence, early detection, high-risk groups, immune microenvironment, tumour microbiome, tumour stroma
Divisions:	Faculty of Health and Life Sciences Faculty of Health and Life Sciences > Institute of Systems, Molecular and Integrative Biology
Depositing User:	Symplectic Admin
Date Deposited:	21 Apr 2022 08:02
Last Modified:	02 Feb 2023 21:27
DOI:	10.12703/r/11-9
Related URLs:	Author Publisher
URI:	https://livrepository.liverpool.ac.uk/id/eprint/3153464