Anatomical and functional outcomes of pneumatic vitreolysis for treatment of vitreomacular traction with and without macular holes.

Baumann, Carmen ORCID: 0000-0001-8662-0582, Sabatino, Francesco, Zheng, Yalin ORCID: 0000-0002-7873-0922, Johannigmann-Malek, Navid, Maier, Mathias, Kaye, Stephen B ORCID: 0000-0003-0390-0592 and Patton, Niall (2022) Anatomical and functional outcomes of pneumatic vitreolysis for treatment of vitreomacular traction with and without macular holes. Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie, 260 (7). pp. 2209-2215.

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Official URL: http://dx.doi.org/10.1007/s00417-022-05568-y

Abstract

<h4>Purpose</h4>To evaluate the outcome of pneumatic vitreolysis (PVL) for vitreomacular traction (VMT) with or without full thickness macular hole (MH) < 400 µm.<h4>Methods</h4>Forty-seven eyes of 47 patients were included who had undergone PVL for VMT with or without MH. Main outcome measures were release of VMT, MH closure, best-corrected visual acuity (BCVA) and adverse events.<h4>Results</h4>Thirty-three patients had isolated VMT and 14 patients VMT with a MH. Four weeks after PVL, the overall VMT release rate was 35/47 (74.5%): 25/37 (67.6%) in phakic and 10/10 (100%) in pseudophakic eyes (p = 0.03). Four of 14 MH (28.6%) were closed. Twenty-two of 47 (46.8%) eyes required a subsequent PPV: 12/33 (36.4%) in the VMT only group and 10/14 (71.4%) in the VMT with MH group. Mean BCVA improved from 0.48 (± 0.24) to 0.34 (± 0.23) logMAR at 6 months in patients with VMT alone (p < 0.001), and from 0.57 (± 0.27) to 0.41 (± 0.28) logMAR in patients with VMT and MH (p = 0.008). Adverse events included new formation of a large MH in 4/33 (12.1%) eyes, failure of MH closure in 10/14 (71.4%) eyes, progression of mean minimum linear diameter (MLD) MH size from baseline 139 (± 67) to 396 (± 130) µm (p < 0.001) and development of a retinal detachment in 4/47 (8.5%) eyes.<h4>Conclusion</h4>While PVL leads to a high VMT release rate particularly in pseudophakic eyes, it is associated with a relatively high incidence of MH formation, MH size progression and retinal detachment.

Item Type:	Article
Uncontrolled Keywords:	Humans, Retinal Detachment, Retinal Perforations, Vitreous Detachment, Peptide Fragments, Tomography, Optical Coherence, Traction, Retrospective Studies, Visual Acuity, Fibrinolysin, Intravitreal Injections
Divisions:	Faculty of Health and Life Sciences Faculty of Health and Life Sciences > Institute of Life Courses and Medical Sciences
Depositing User:	Symplectic Admin
Date Deposited:	25 Apr 2022 07:59
Last Modified:	18 Jan 2023 21:04
DOI:	10.1007/s00417-022-05568-y
Open Access URL:	https://link.springer.com/article/10.1007/s00417-0...
Related URLs:	Author Publisher
URI:	https://livrepository.liverpool.ac.uk/id/eprint/3153757