Potential Values of Circulating microRNA-21 to Predict Early Recurrence in Patients with Colorectal Cancer after Treatments

Hao, Yun-Jie, Yang, Chih-Yung, Chen, Ming-Hsien, Chang, Lu-Wey, Lin, Chien-Ping, Lo, Liang-Chuan, Huang, Sheng-Chieh, Lyu, You-You, Jiang, Jeng-Kai and Tseng, Fan-Gang (2022) Potential Values of Circulating microRNA-21 to Predict Early Recurrence in Patients with Colorectal Cancer after Treatments. JOURNAL OF CLINICAL MEDICINE, 11 (9). 2400-.

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Abstract

Insufficient prognosis of local recurrence contributes to the poor progression-free survival rate and death in colorectal cancer (CRC) patients. Various biomarkers have been explored in predicting CRC recurrence. This study investigated the expressions of plasma/exosomal microRNA-21 (miR-21) in 113 CRC patients by qPCR, their values of predicting CRC recurrence, and the possibility to improve the prognostic efficacy in early CRC recurrence in stratified patients by combined biomarkers including circulating miR-21s, circulating tumour cells/microemboli (CTCs/CTM), and serum carcinoembryonic antigen (CEA)/carbohydrate antigen 19-9 (CA19-9). Expressions of plasma and exosomal miR-21s were significantly correlated (p < 0.0001) in all and late-stage patients, presenting similar correlations with other biomarkers. However, stage IV patients stratified by a high level of exosomal miR-21 and stage I to III patients stratified by a high level of plasma miR-21 displayed significantly worse survival outcomes in predicting CRC recurrence, suggesting their different values to predict CRC recurrence in stratified patients. Comparable and even better performances in predicting CRC recurrence in late-stage patients were found by CTCs/CTM from our blood samples as sensitive biomarkers. Improved prognosing efficacy in CRC recurrence and better outcomes to significantly differentiate recurrence in stratified patients could be obtained by analysing combined biomarkers.

Item Type:	Article
Uncontrolled Keywords:	plasma microRNA21 (miR-21), exosomal microRNA21 (exo-miR-21), circulating tumour cells (CTCs), circulating tumour microemboli (CTM), carcinoembryonic antigen (CEA), carbohydrate antigen 19-9 (CA19-9), colorectal cancer (CRC), peripheral blood (PB), prognosis, recurrence
Divisions:	Faculty of Science and Engineering > School of Engineering
Depositing User:	Symplectic Admin
Date Deposited:	25 Apr 2022 13:13
Last Modified:	14 Jun 2023 17:57
DOI:	10.3390/jcm11092400
Open Access URL:	https://www.mdpi.com/2077-0383/11/9/2400
Related URLs:	Author Publisher
URI:	https://livrepository.liverpool.ac.uk/id/eprint/3153903