"At first, I was very afraid"-a qualitative description of participants' views and experiences in the first Human Infection Study in Malawi.

Mtunthama Toto, Neema ORCID: 0000-0002-9047-217X, Gooding, Kate, Kapumba, Blessings M ORCID: 0000-0002-8210-3454, Jambo, Kondwani ORCID: 0000-0002-3195-2210, Rylance, Jamie ORCID: 0000-0002-2323-3611, Burr, Sarah, Morton, Ben ORCID: 0000-0002-6164-2854, Gordon, Stephen B ORCID: 0000-0001-6576-1116 and Manda-Taylor, Lucinda ORCID: 0000-0001-8149-0897 (2021) "At first, I was very afraid"-a qualitative description of participants' views and experiences in the first Human Infection Study in Malawi. Wellcome open research, 6. 89-.

Access the full-text of this item by clicking on the Open Access link.

Official URL: http://dx.doi.org/10.12688/wellcomeopenres.16587.2

Abstract

Background: Human infection studies (HIS) involve deliberately infecting healthy volunteers with a pathogen in a controlled environment to understand infection and support the development of effective vaccines or treatments. HIS research is expanding to many low and middle-income settings to accelerate vaccine development. Given the implementation of the first HIS research to establish the experimental human pneumococcal carriage model's feasibility, we sought to understand the participant's opinions and experiences. Methods: We used a qualitative, descriptive approach to understand participants perceptions and experiences on HIS participation. Sixteen healthy adult participants were invited to participate in in-depth exit interviews to discuss their experiences, motivations and concerns. Results: Our findings showed that the likelihood of participation in HIS research rests on three essential conditions: motivation to participate, compensation and advocacy. The motivation and decision to participate was based on reasons including altruism, patriotism, monetary and material incentives, and while compensation was deemed appropriate, concerns about unanticipated research-related risks were raised. Participant advocate groups were recommended for increasing awareness and educating others in the broader community about HIS research. Conclusions: Participants' experiences of HIS in Malawi provide the basis of what can be acceptable in HIS research in lower-income countries and areas where study procedures could be adjusted.

Item Type:	Article
Uncontrolled Keywords:	Human infection studies, Malawi, acceptability, ethics
Divisions:	Faculty of Health and Life Sciences Faculty of Health and Life Sciences > Institute of Infection, Veterinary and Ecological Sciences
Depositing User:	Symplectic Admin
Date Deposited:	03 May 2022 14:48
Last Modified:	18 Jan 2023 21:04
DOI:	10.12688/wellcomeopenres.16587.2
Open Access URL:	https://wellcomeopenresearch.org/articles/6-89/v2
Related URLs:	Author Publisher
URI:	https://livrepository.liverpool.ac.uk/id/eprint/3154221