Utembe, W, Tlotleng, N and Kamng'ona, Aw 
ORCID: 0000-0002-0841-7586
(2022)
A systematic review on the effects of nanomaterials on gut microbiota.
CURRENT RESEARCH IN MICROBIAL SCIENCES, 3.
100118-.
Abstract
Some nanomaterials (NMs) have been shown to possess antimicrobial activity and cause GM dysbiosis. Since NMs are being used widely, a systematic assessment of the effects of NMs on GM is warranted. In this systematic review, a total of 46 <i>in vivo</i> and 22 <i>in vitro</i> studies were retrieved from databases and search engines including Science-Direct, Pubmed and Google scholar. Criteria for assessment of studies included use of <i>in vitro</i> or <i>in vivo</i> studies, characterization of NMs, use of single or multiple doses as well as consistency of results. GM dysbiosis has been studied most widely on TiO<sub>2</sub>, Ag, Zn-based NMs. There was moderate evidence for GM dysbiosis caused by Zn- and Cu-based NMs, Cu-loaded chitosan NPs and Ag NMs, and anatase TiO<sub>2</sub> NPs, as well as low evidence for SWCNTs, nanocellulose, SiO<sub>2</sub>, Se, nanoplastics, CeO<sub>2,</sub> MoO<sub>3</sub> and graphene-based NMs. Most studies indicate adverse effects of NMs towards GM. However, more work is required to elucidate the differences on the reported effects of NM by type and sex of organisms, size, shape and surface properties of NMs as well as effects of exposure to mixtures of NMs. For consistency and better agreement among studies on GM dysbiosis, there is need for internationally agreed protocols on, <i>inter alia,</i> characterization of NMs, dosing (amounts, frequency and duration), use of sonication, test systems (both in vitro and <i>in vivo</i>), including oxygen levels for <i>in vitro</i> models.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | Nanomaterials, Gut microbiota, Dysbiosis, Exposure, Metabolic disease |
| Divisions: | Faculty of Health and Life Sciences Faculty of Health and Life Sciences > Institute of Infection, Veterinary and Ecological Sciences |
| Depositing User: | Symplectic Admin |
| Date Deposited: | 03 May 2022 15:17 |
| Last Modified: | 13 Aug 2023 21:58 |
| DOI: | 10.1016/j.crmicr.2022.100118 |
| Open Access URL: | https://www.sciencedirect.com/science/article/pii/... |
| Related URLs: | |
| URI: | https://livrepository.liverpool.ac.uk/id/eprint/3154230 |
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