Millward, Christopher P 
ORCID: 0000-0001-7727-1157, Armstrong, Terri S, Barrington, Heather, Brodbelt, Andrew R, Bulbeck, Helen, Byrne, Anthony, Dirven, Linda, Gamble, Carrol ORCID: 0000-0002-3021-1955, Grundy, Paul L, Islim, Abdurrahman I et al (show 20 more authors)
(2022)
Opportunities and challenges for the development of "core outcome sets" in neuro-oncology.
NEURO-ONCOLOGY, 24 (7).
pp. 1048-1055.
Abstract
Core Outcome Sets (COS) define minimum outcomes to be measured and reported in clinical effectiveness trials for a particular health condition/health area. Despite recognition as critical to clinical research design for other health areas, none have been developed for neuro-oncology. COS development projects should carefully consider: scope (how the COS should be used), stakeholders involved in development (including patients as both research partners and participants), and consensus methodologies used (typically a Delphi survey and consensus meeting), as well as dissemination plans. Developing COS for neuro-oncology is potentially challenging due to extensive tumor subclassification (including molecular stratification), different symptoms related to anatomical tumor location, and variation in treatment options. Development of a COS specific to tumor subtype, in a specific location, for a particular intervention may be too narrow and would be unlikely to be used. Equally, a COS that is applicable across a wider area of neuro-oncology may be too broad and therefore lack specificity. This review describes why and how a COS may be developed, and discusses challenges for their development, specific to neuro-oncology. The COS under development are briefly described, including: adult glioma, incidental/untreated meningioma, meningioma requiring intervention, and adverse events from surgical intervention for pediatric brain tumors.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | core outcome set, clinical trial, effectiveness, glioma, meningioma |
| Divisions: | Faculty of Health and Life Sciences Faculty of Health and Life Sciences > Institute of Systems, Molecular and Integrative Biology |
| Depositing User: | Symplectic Admin |
| Date Deposited: | 04 May 2022 10:11 |
| Last Modified: | 18 Jan 2023 21:04 |
| DOI: | 10.1093/neuonc/noac062 |
| Open Access URL: | https://doi.org/10.1093/neuonc/noac062 |
| Related URLs: | |
| URI: | https://livrepository.liverpool.ac.uk/id/eprint/3154268 |
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