Frequent premature atrial contractions as a signalling marker of atrial cardiomyopathy, incident atrial fibrillation, and stroke

Farinha, Jose Maria, Gupta, Dhiraj and Lip, Gregory YH ORCID: 0000-0002-7566-1626 (2023) Frequent premature atrial contractions as a signalling marker of atrial cardiomyopathy, incident atrial fibrillation, and stroke. CARDIOVASCULAR RESEARCH, 119 (2). pp. 429-439.

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Official URL: http://dx.doi.org/10.1093/cvr/cvac054

Abstract

Premature atrial contractions are a common cardiac phenomenon. Although previously considered a benign electrocardiographic finding, they have now been associated with a higher risk of incident atrial fibrillation (AF) and other adverse outcomes such as stroke and all-cause mortality. Since premature atrial contractions can be associated with these adverse clinical outcomes independently of AF occurrence, different explanations have being proposed. The concept of atrial cardiomyopathy, where AF would be an epiphenomenon outside the causal pathway between premature atrial contractions and stroke has received traction recently. This concept suggests that structural, functional, and biochemical changes in the atria lead to arrhythmia occurrence and thromboembolic events. Some consensus about diagnosis and treatment of this condition have been published, but this is based on scarce evidence, highlighting the need for a clear definition of excessive premature atrial contractions and for prospective studies regarding antiarrhythmic therapies, anticoagulation or molecular targets in this group of patients.

Item Type:	Article
Uncontrolled Keywords:	Anticoagulation, Atrial cardiomyopathy, Atrial myopathy, Premature atrial contractions, Supraventricular ectopic beats, Stroke
Divisions:	Faculty of Health and Life Sciences Faculty of Health and Life Sciences > Institute of Life Courses and Medical Sciences
Depositing User:	Symplectic Admin
Date Deposited:	06 May 2022 16:00
Last Modified:	17 Jun 2023 16:22
DOI:	10.1093/cvr/cvac054
Open Access URL:	https://academic.oup.com/cardiovascres/advance-art...
Related URLs:	Author Publisher
URI:	https://livrepository.liverpool.ac.uk/id/eprint/3154400