Cornick, Jennifer, Musicha, Patrick, Peno, Chikondi, Seager, Ezgi, Tam, Pui-Ying Iroh, Bilima, Sithembile, Bennett, Aisleen, Kennedy, Neil, Feasey, Nicholas, Heinz, Eva et al (show 1 more authors)
(2021)
Genomic investigation of a suspected Klebsiella pneumoniae outbreak in a neonatal care unit in sub- Saharan Africa.
MICROBIAL GENOMICS, 7 (11).
000703-.
Abstract
A special-care neonatal unit from a large public hospital in Malawi was noted as having more frequent, difficult-to-treat infections, and a suspected outbreak of multi-drug-resistant <i>Klebsiella pneumoniae</i> was investigated using genomic characterisation. All <i>K. pneumoniae</i> bloodstream infections (BSIs) from patients in the neonatal ward (<i>n</i>=62), and a subset of <i>K. pneumoniae</i> BSI isolates (<i>n</i>=38) from other paediatric wards in the hospital, collected over a 4 year period were studied. After whole genome sequencing, the strain sequence types (STs), plasmid types, virulence and resistance genes were identified. One ST340 clone, part of clonal complex 258 (CC258) and an ST that drives hospital outbreaks worldwide, harbouring numerous resistance genes and plasmids, was implicated as the likely cause of the outbreak. This study contributes molecular information necessary for tracking and characterizing this important hospital pathogen in sub-Saharan Africa.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | antimicrobial resistance, genome sequencing, hospital outbreak, Klebsiella pneumoniae, neonatal infection, sub-Saharan Africa |
| Divisions: | Faculty of Health and Life Sciences Faculty of Health and Life Sciences > Institute of Infection, Veterinary and Ecological Sciences |
| Depositing User: | Symplectic Admin |
| Date Deposited: | 09 May 2022 09:03 |
| Last Modified: | 15 Mar 2024 03:16 |
| DOI: | 10.1099/mgen.0.000703 |
| Open Access URL: | https://doi.org/10.1099/mgen.0.000703 |
| Related URLs: | |
| URI: | https://livrepository.liverpool.ac.uk/id/eprint/3154489 |
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