Kraemer, Moritz UG, Hill, Verity, Ruis, Christopher, Dellicour, Simon, Bajaj, Sumali, McCrone, John T, Baele, Guy, Parag, Kris V, Battle, Anya Lindström, Gutierrez, Bernardo et al (show 14 more authors)
(2021)
Spatiotemporal invasion dynamics of SARS-CoV-2 lineage B.1.1.7 emergence.
Science, 373 (6557).
pp. 889-895.
Abstract
<jats:title>Fueling outbreaks</jats:title> <jats:p> The B.1.1.7 lineage of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has caused fast-spreading outbreaks globally. Intrinsically, this variant has greater transmissibility than its predecessors, but this capacity has been amplified in some circumstances to tragic effect by a combination of human behavior and local immunity. What are the extrinsic factors that help or hinder the rapid dissemination of variants? Kraemer <jats:italic>et al</jats:italic> . explored the invasion dynamics of B.1.1.7. in fine detail, from its location of origin in Kent, UK, to its heterogenous spread around the country. A combination of mobile phone and virus data including more than 17,000 genomes shows how distinct phases of dispersal were related to intensity of mobility and the timing of lockdowns. As the local outbreaks grew, importation from the London source area became less important. Had B.1.1.7. emerged at a slightly different time of year, its impact might have been different. —CA </jats:p>
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | COVID-19 Genomics UK (COG-UK) Consortium, Humans, Incidence, Communicable Disease Control, Genome, Viral, Travel, Phylogeography, Spatio-Temporal Analysis, United Kingdom, COVID-19, SARS-CoV-2, COVID-19 Nucleic Acid Testing |
| Divisions: | Faculty of Health and Life Sciences Faculty of Health and Life Sciences > Institute of Infection, Veterinary and Ecological Sciences |
| Depositing User: | Symplectic Admin |
| Date Deposited: | 12 May 2022 10:18 |
| Last Modified: | 16 Dec 2023 03:36 |
| DOI: | 10.1126/science.abj0113 |
| Open Access URL: | https://www.science.org/doi/10.1126/science.abj011... |
| Related URLs: | |
| URI: | https://livrepository.liverpool.ac.uk/id/eprint/3154671 |
Dimensions
Dimensions
