Optimal Scaling Approaches for Perfusion MRI with Distorted Arterial Input Function (AIF) in Patients with Ischemic Stroke

Bal, Sukhdeep Singh ORCID: 0000-0001-6942-2859, Yang, Fan Pei Gloria, Sung, Yueh-Feng, Chen, Ke ORCID: 0000-0002-6093-6623, Yin, Jiu-Haw and Peng, Giia-Sheun (2022) Optimal Scaling Approaches for Perfusion MRI with Distorted Arterial Input Function (AIF) in Patients with Ischemic Stroke. BRAIN SCIENCES, 12 (1). 77-.

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Official URL: http://dx.doi.org/10.3390/brainsci12010077

Abstract

<h4>Background</h4>Diagnosis and timely treatment of ischemic stroke depends on the fast and accurate quantification of perfusion parameters. Arterial input function (AIF) describes contrast agent concentration over time as it enters the brain through the brain feeding artery. AIF is the central quantity required to estimate perfusion parameters. Inaccurate and distorted AIF, due to partial volume effects (PVE), would lead to inaccurate quantification of perfusion parameters.<h4>Methods</h4>Fifteen patients suffering from stroke underwent perfusion MRI imaging at the Tri-Service General Hospital, Taipei. Various degrees of the PVE were induced on the AIF and subsequently corrected using rescaling methods.<h4>Results</h4>Rescaled AIFs match the exact reference AIF curve either at peak height or at tail. Inaccurate estimation of CBF values estimated from non-rescaled AIFs increase with increasing PVE. Rescaling of the AIF using all three approaches resulted in reduced deviation of CBF values from the reference CBF values. In most cases, CBF map generated by rescaled AIF approaches show increased CBF and Tmax values on the slices in the left and right hemispheres.<h4>Conclusion</h4>Rescaling AIF by VOF approach seems to be a robust and adaptable approach for correction of the PVE-affected multivoxel AIF. Utilizing an AIF scaling approach leads to more reasonable absolute perfusion parameter values, represented by the increased mean CBF/Tmax values and CBF/Tmax images.

Item Type:	Article
Uncontrolled Keywords:	PVE (partial volume effect), CBF (cerebral blood flow), AIF (arterial input function), CBV (cerebral blood volume), SVD (singular value decomposition)
Divisions:	Faculty of Science and Engineering > School of Physical Sciences
Depositing User:	Symplectic Admin
Date Deposited:	12 May 2022 14:24
Last Modified:	10 Feb 2024 02:59
DOI:	10.3390/brainsci12010077
Open Access URL:	https://www.mdpi.com/2076-3425/12/1/77
Related URLs:	Author Publisher
URI:	https://livrepository.liverpool.ac.uk/id/eprint/3154673