Corica, Bernadette 
ORCID: 0000-0001-9460-4435, Romiti, Giulio Francesco, Basili, Stefania and Proietti, Marco ORCID: 0000-0003-1452-2478
(2022)
Prevalence of New-Onset Atrial Fibrillation and Associated Outcomes in Patients with Sepsis: A Systematic Review and Meta-Analysis.
JOURNAL OF PERSONALIZED MEDICINE, 12 (4).
547-.
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Prevalence of New-Onset Atrial Fibrillation and Associated Outcomes in Patients with Sepsis A Systematic Review and Meta-Ana.pdf - Published version Download (1MB) | Preview |
Abstract
<h4>Background</h4>New-onset atrial fibrillation (NOAF) is a common complication in patients with sepsis, although its prevalence and impact on outcomes are still unclear. We aim to provide a systematic review and meta-analysis on the prevalence of NOAF in patients with sepsis, and its impact on in-hospital mortality and intensive care unit (ICU) mortality.<h4>Methods</h4>PubMed and EMBASE were systematically searched on 26 December 2021. Studies reporting on the prevalence of NOAF and/or its impact on in-hospital mortality or ICU mortality in patients with sepsis or septic shock were included. The pooled prevalence and 95% confidence intervals (CI) were calculated, as well as the risk ratios (RR), 95%CI and 95% prediction intervals (PI) for outcomes. Subgroup analyses and meta-regressions were performed to account for heterogeneity.<h4>Results</h4>Among 4988 records retrieved from the literature search, 22 articles were included. Across 207,847 patients with sepsis, NOAF was found in 13.5% (95%CI: 8.9-20.1%), with high heterogeneity between studies; significant subgroup differences were observed, according to the geographical location, study design and sample size of the included studies. A multivariable meta-regression model showed that sample size and geographical location account for most of the heterogeneity. NOAF patients showed an increased risk of both in-hospital mortality (RR: 1.69, 95%CI: 1.47-1.96, 95%PI: 1.15-2.50) and ICU mortality (RR: 2.12, 95%CI: 1.86-2.43, 95%PI: 1.71-2.63), with moderate to no heterogeneity between the included studies.<h4>Conclusions</h4>NOAF is a common complication during sepsis, being present in one out of seven individuals. Patients with NOAF are at a higher risk of adverse events during sepsis, and may need specific therapeutical interventions.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | atrial fibrillation, sepsis, septic shock, prognosis, meta-analysis |
| Divisions: | Faculty of Health and Life Sciences Faculty of Health and Life Sciences > Institute of Life Courses and Medical Sciences |
| Depositing User: | Symplectic Admin |
| Date Deposited: | 13 May 2022 14:47 |
| Last Modified: | 18 Jan 2023 21:03 |
| DOI: | 10.3390/jpm12040547 |
| Open Access URL: | https://www.mdpi.com/2075-4426/12/4/547 |
| Related URLs: | |
| URI: | https://livrepository.liverpool.ac.uk/id/eprint/3154759 |
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