Corica, Bernadette 
ORCID: 0000-0001-9460-4435, Marra, Alberto Maria, Basili, Stefania, Cangemi, Roberto, Cittadini, Antonio, Proietti, Marco ORCID: 0000-0003-1452-2478 and Romiti, Giulio Francesco
(2021)
Prevalence of right ventricular dysfunction and impact on all-cause death in hospitalized patients with COVID-19: a systematic review and meta-analysis.
SCIENTIFIC REPORTS, 11 (1).
17774-.
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Prevalence of right ventricular dysfunction and impact on all-cause death in hospitalized patients with COVID-19 a systemati.pdf - Published version Download (2MB) | Preview |
Abstract
The Coronavirus Disease (COVID-19) pandemic imposed a high burden of morbidity and mortality. In COVID-19, direct lung parenchymal involvement and pulmonary microcirculation dysfunction may entail pulmonary hypertension (PH). PH and direct cardiac injury beget right ventricular dysfunction (RVD) occurrence, which has been frequently reported in COVID-19 patients; however, the prevalence of RVD and its impact on outcomes during COVID-19 are still unclear. This study aims to evaluate the prevalence of RVD and associated outcomes in patients with COVID-19, through a Systematic Review and Meta-Analysis. MEDLINE and EMBASE were systematically searched from inception to 15th July 2021. All studies reporting either the prevalence of RVD in COVID-19 patients or all-cause death according to RVD status were included. The pooled prevalence of RVD and Odds Ratio (OR) for all-cause death according to RVD status were computed and reported. Subgroup analysis and meta-regression were also performed. Among 29 studies (3813 patients) included, pooled prevalence of RVD was 20.4% (95% CI 17.1-24.3%; 95% PI 7.8-43.9%), with a high grade of heterogeneity. No significant differences were found across geographical locations, or according to the risk of bias. Severity of COVID-19 was associated with increased prevalence of RVD at meta-regression. The presence of RVD was found associated with an increased likelihood of all-cause death (OR 3.32, 95% CI 1.94-5.70). RVD was found in 1 out of 5 COVID-19 patients, and was associated with all-cause mortality. RVD may represent one crucial marker for prognostic stratification in COVID-19; further prospective and larger are needed to investigate specific management and therapeutic approach for these patients.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | Humans, Ventricular Dysfunction, Right, Prognosis, Hospitalization, Prevalence, Cause of Death, Hospital Mortality, Risk Assessment, Risk Factors, Pandemics, COVID-19, SARS-CoV-2 |
| Divisions: | Faculty of Health and Life Sciences Faculty of Health and Life Sciences > Institute of Life Courses and Medical Sciences |
| Depositing User: | Symplectic Admin |
| Date Deposited: | 13 May 2022 14:48 |
| Last Modified: | 18 Jan 2023 21:03 |
| DOI: | 10.1038/s41598-021-96955-8 |
| Open Access URL: | https://www.nature.com/articles/s41598-021-96955-8 |
| Related URLs: | |
| URI: | https://livrepository.liverpool.ac.uk/id/eprint/3154760 |
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