Prognosis of Atrial Fibrillation with or without Comorbidities: Analysis of Younger Adults from a Nationwide Database.

Mertz, Valentin, Cottin, Yves ORCID: 0000-0002-5176-5121, Bentounes, Sid Ahmed, Pastier-Debeaumarché, Julie, Didier, Romain ORCID: 0000-0003-3735-9204, Herbert, Julien, Zeller, Marianne ORCID: 0000-0002-5763-4579, Lip, Gregory YH ORCID: 0000-0002-7566-1626 and Fauchier, Laurent ORCID: 0000-0002-9267-1658 (2022) Prognosis of Atrial Fibrillation with or without Comorbidities: Analysis of Younger Adults from a Nationwide Database. Journal of clinical medicine, 11 (7). 1981-.

Access the full-text of this item by clicking on the Open Access link.

Text
Prognosis of Atrial Fibrillation with or without Comorbidities Analysis of Younger Adults from a Nationwide Database.pdf - Published version
Download (1MB) | Preview

Official URL: http://dx.doi.org/10.3390/jcm11071981

Abstract

Objective: To assess the prognosis of AF patients with or without cardiac or extra-cardiac concomitant conditions. Participants and Methods: All consecutive patients diagnosed with AF admitted to French hospitals between 2011 and 2020 were identified. Patients were classified into four groups: (1) > 60 yo; (2) with known cardiac disease (KCD group); (3) with extra-cardiac comorbidities (ECC); and 4) AF without KCD or ECC (“Lone AF”). Results: Altogether 2,435,541 patients were identified, from which 2,203,702 patients aged >60 years and 231,839 patients aged <60 years (with KCD (55.2%), with ECC (14.7%) and with “Lone AF” (30.1%)). During follow-up, the incidences of all-cause and CV deaths were 13.7%, 5.7%, 6.2%, and 2.3%, and 4.2%, 1.7%, 0.8%, and 0.3% in the older than 60 yo group, KCD group, ECC group and “Lone AF” AF group, respectively. In the age and sex-adjusted analysis (patients < 60 yo), patients with AF and KCD had worse outcomes than patients with “Lone AF” for all major cardiac events. Conclusion: There are three distinct prognostic criteria based on the presence or lack of HD or extra-cardiac concomitant comorbidities. Patients in the so-called “Lone AF” group remain severe in terms of CV events but still with a lower incidence than the patients with associated KCD or ECC. The presence of KCD or ECC makes it possible to distinguish a profile in terms of events that are very different between the patients.

Item Type:	Article
Uncontrolled Keywords:	atrial fibrillation, comorbidities, heart disease, heart failure, mortality, prognosis, stroke
Divisions:	Faculty of Health and Life Sciences Faculty of Health and Life Sciences > Institute of Life Courses and Medical Sciences
Depositing User:	Symplectic Admin
Date Deposited:	13 May 2022 14:51
Last Modified:	14 Mar 2023 20:28
DOI:	10.3390/jcm11071981
Open Access URL:	https://www.mdpi.com/2077-0383/11/7/1981
Related URLs:	Author Publisher
URI:	https://livrepository.liverpool.ac.uk/id/eprint/3154761