Farrow, Thomas, Laumier, Siriny, Sandall, Ian 
ORCID: 0000-0003-3532-0373 and van Zalinge, Harm ORCID: 0000-0003-0996-1281
(2022)
An Aptamer-Functionalised Schottky-Field Effect Transistor for the Detection of Proteins.
Biosensors, 12 (5).
p. 347.
Abstract
<jats:p>The outbreak of the coronavirus disease 2019 (COVID-19) in December 2019 has highlighted the need for a flexible sensing system that can quickly and accurately determine the presence of biomarkers associated with the disease. This sensing system also needs to be easily adaptable to incorporate both novel diseases as well as changes in the existing ones. Here we report the feasibility of using a simple, low-cost silicon field-effect transistor functionalised with aptamers and designed to attach to the spike protein of SARS-CoV2. It is shown that a linear response can be obtained in a concentration range of 100 fM to 10 pM. Furthermore, by using a larger range of source-drain potentials compared with other FET based sensors, it is possible to look at a wider range of device parameters to optimise the response.</jats:p>
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | biosensors, thin film sensors, field effect transistors, aptamers |
| Divisions: | Faculty of Science and Engineering > School of Electrical Engineering, Electronics and Computer Science |
| Depositing User: | Symplectic Admin |
| Date Deposited: | 18 May 2022 11:12 |
| Last Modified: | 18 Jan 2023 21:01 |
| DOI: | 10.3390/bios12050347 |
| Open Access URL: | https://www.mdpi.com/2079-6374/12/5/347 |
| Related URLs: | |
| URI: | https://livrepository.liverpool.ac.uk/id/eprint/3155038 |
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