De Pergola, Giovanni, Castellana, Fabio, Zupo, Roberta, De Nucci, Sara, Panza, Francesco, Castellana, Marco, Lampignano, Luisa, Di Chito, Martina, Triggiani, Vincenzo, Sardone, Rodolfo 
ORCID: 0000-0003-1383-1850 et al (show 1 more authors)
(2021)
A family history of type 2 diabetes as a predictor of fatty liver disease in diabetes-free individuals with excessive body weight.
SCIENTIFIC REPORTS, 11 (1).
24084-.
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Abstract
Comprehensive screening for non-alcoholic fatty liver disease (NAFLD) may help prompt clinical management of fatty liver disease. A family history, especially of diabetes, has been little studied as a predictor for NAFLD. We characterized the cross-sectional relationship between a family history of type 2 diabetes (FHT2D) and NAFLD probability in 1185 diabetes-free Apulian (Southern-Italy) subjects aged > 20 years with overweight or obesity not receiving any drug or supplementation. Clinical data and routine biochemistry were analysed. NAFLD probability was defined using the fatty liver index (FLI). A first-degree FHT2D was assessed by interviewing subjects and assigning a score of 0, 1, or 2 if none, only one, or both parents were affected by type 2 diabetes mellitus (T2DM). Our study population featured most females (70.9%, N = 840), and 48.4% (N = 574) of the sample had first-degree FHT2D. After dividing the sample by a FHT2D, we found a higher BMI, Waist Circumference (WC), and diastolic blood pressure shared by FHT2D subjects; they also showed altered key markers of glucose homeostasis, higher triglyceride levels, and worse liver function. FLI scores were significantly lower in subjects without a first-degree FHT2D. After running logistic regression models, a FHT2D was significantly associated with the NAFLD probability, even adjusting for major confounders and stratifying by age (under and over 40 years of age). A FHT2D led to an almost twofold higher probability of NAFLD, regardless of confounding factors (OR 2.17, 95% CI 1.63 to 2.89). A first-degree FHT2D acts as an independent determinant of NAFLD in excess weight phenotypes, regardless of the age group (younger or older than 40 years). A NAFLD risk assessment within multidimensional screening might be useful in excess weight subjects reporting FHT2D even in the absence of diabetes.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | Humans, Diabetes Mellitus, Type 2, Medical History Taking, Body Mass Index, Logistic Models, Probability, Risk Assessment, Cross-Sectional Studies, Forecasting, Adult, Aged, Middle Aged, Italy, Female, Male, Overweight, Waist Circumference, Young Adult, Non-alcoholic Fatty Liver Disease |
| Divisions: | Faculty of Health and Life Sciences Faculty of Health and Life Sciences > Institute of Life Courses and Medical Sciences |
| Depositing User: | Symplectic Admin |
| Date Deposited: | 20 May 2022 13:37 |
| Last Modified: | 18 Jan 2023 21:01 |
| DOI: | 10.1038/s41598-021-03583-3 |
| Open Access URL: | https://www.nature.com/articles/s41598-021-03583-3 |
| Related URLs: | |
| URI: | https://livrepository.liverpool.ac.uk/id/eprint/3155220 |
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