Liso, Marina, Sila, Annamaria, Verna, Giulio, Scarano, Aurelia, Donghia, Rossella, Castellana, Fabio, Cavalcanti, Elisabetta, Pesole, Pasqua Letizia, Sommella, Eduardo Maria, Lippolis, Antonio et al (show 11 more authors)
(2022)
Nutritional Regimes Enriched with Antioxidants as an Efficient Adjuvant for IBD Patients under Infliximab Administration, a Pilot Study.
ANTIOXIDANTS, 11 (1).
138-.
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Nutritional Regimes Enriched with Antioxidants as an Efficient Adjuvant for IBD Patients under Infliximab Administration, a .pdf - Published version Download (904kB) | Preview |
Abstract
Antioxidants are privileged candidates for the development of adjuvants able to improve the efficiency of pharmacological therapies, particularly for chronic inflammatory syndromes. During the last 20 years, anti-TNFα (tumor necrosis factor alpha) monoclonal antibodies infusion has been the biological therapy most frequently administered but there is still large space for improvement in disease remission rates and maintenance. In this context, nutritional bioactive compounds contained in dietary patterns or included as supplements, may act as adjuvants for the induction and maintenance of IBD (inflammatory bowel diseases) remission. To verify this possibility, a single-center preliminary study (SI-CURA, Soluzioni Innovative per la gestione del paziente e il follow up terapeutico della Colite UlceRosA) was designed and carried out to evaluate whether a daily administration of purple corn supplement could improve the response to Infliximab (IFX) infusion of IBD patients with both Crohn's disease (CD) and ulcerative colitis (UC). A cohort of 47 patients was enrolled in the study. Biological samples were collected before the first and the third IFX infusion. All patients received nutritional guidelines, 27 of them received commercial red fruit tea with low anthocyanins content, while 20 received a purple corn supplement with a high anthocyanin content. Results show that the administration of an antioxidant-enriched purple corn supplement could improve IFX-mediated disease remission in terms of circulating inflammatory markers. Comparison between CD and UC patients revealed that, at this anthocyanin dosage, the purple corn extract administration improved the IFX response in CD but not in UC patients. Our results may pave the way for a new metacentric study of CD patients, recruiting a wider cohort and followed-up over a longer observational time.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | antioxidant, anthocyanins, IBD, diet, infliximab, pilot study |
| Divisions: | Faculty of Health and Life Sciences Faculty of Health and Life Sciences > Institute of Life Courses and Medical Sciences |
| Depositing User: | Symplectic Admin |
| Date Deposited: | 20 May 2022 15:07 |
| Last Modified: | 18 Jan 2023 21:01 |
| DOI: | 10.3390/antiox11010138 |
| Open Access URL: | https://www.mdpi.com/2076-3921/11/1/138 |
| Related URLs: | |
| URI: | https://livrepository.liverpool.ac.uk/id/eprint/3155237 |
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