Importance of antimicrobial stewardship in solid organ transplant recipients: An ESCMID perspective.

Ioannou, Petros ORCID: 0000-0003-1082-5674, Karakonstantis, Stamatis, Schouten, Jeroen, Kostyanev, Tomislav ORCID: 0000-0002-1259-4876, Charani, Esmita ORCID: 0000-0002-5938-1202, Vlahovic-Palcevski, Vera, Kofteridis, Diamantis P ORCID: 0000-0001-7603-2592 and Supported by the ESCMID Study Group for Antimicrobial Stewardshi, (2022) Importance of antimicrobial stewardship in solid organ transplant recipients: An ESCMID perspective. Transplant infectious disease : an official journal of the Transplantation Society, 24 (5). e13852-.

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Official URL: http://dx.doi.org/10.1111/tid.13852

Abstract

<h4>Background</h4>In the last decades, solid organ transplantation (SOT) has emerged as an important method in the management of chronic kidney, liver, heart, and lung failure. Antimicrobial use has led to a significant reduction of morbidity and mortality due to infectious complications among patients with SOT; however, it can lead to adverse events and drive the development of antimicrobial resistance; thus, antimicrobial stewardship is of extreme importance. Even though there are ongoing efforts of transplant societies to implement principles of antimicrobial stewardship in everyday practice in SOT, there is still a lack of guidelines in this patient population.<h4>Aim</h4>The aim of this study was to review the status of antimicrobial stewardship in patients with SOT, highlight its importance from the perspective of an ongoing vivid dialogue among ESCMID experts in the field of antimicrobial stewardship, and depict opportunities for future study in the field.<h4>Review</h4>Antimicrobial stewardship programs are important in order to allow appropriate initiation and termination of antimicrobials in SOT recipients, and also aid in the most appropriate dosing and choosing of the route of administration of antimicrobials. Application of already known antimicrobial stewardship principles and application of currently used biomarkers and newly developed molecular rapid diagnostic testing tools can aid to the rationalization of antimicrobial prescribing and to a more targeted treatment of infections. Finally, physicians caring for SOT recipients should be actively involved in antimicrobial stewardship in order to assure optimization of antimicrobial prescribing and become familiar with the principles of antimicrobial stewardship.

Item Type:	Article
Uncontrolled Keywords:	Supported by the ESCMID Study Group for Antimicrobial Stewardship - ESGAP, Humans, Anti-Infective Agents, Anti-Bacterial Agents, Organ Transplantation, Transplant Recipients, Antimicrobial Stewardship
Divisions:	Faculty of Health and Life Sciences Faculty of Health and Life Sciences > Institute of Systems, Molecular and Integrative Biology
Depositing User:	Symplectic Admin
Date Deposited:	23 May 2022 15:16
Last Modified:	16 Mar 2024 02:37
DOI:	10.1111/tid.13852
Related URLs:	Author Publisher
URI:	https://livrepository.liverpool.ac.uk/id/eprint/3155351