Bouaoud, Jebrane, Bossi, Paolo, Elkabets, Moshe, Schmitz, Sandra, van Kempen, Leon C, Martinez, Pierre, Jagadeeshan, Sankar, Breuskin, Ingrid, Puppels, Gerwin J, Hoffmann, Caroline et al (show 8 more authors)
(2022)
Unmet Needs and Perspectives in Oral Cancer Prevention.
CANCERS, 14 (7).
1815-.
Abstract
Oral potentially malignant disorders (OPMD) may precede oral squamous cell carcinoma (OSCC). Reported rates of malignant transformation of OPMD range from 3 to 50%. While some clinical, histological, and molecular factors have been associated with a high-risk OPMD, they are, to date, insufficiently accurate for treatment decision-making. Moreover, this range highlights differences in the clinical definition of OPMD, variation in follow-up periods, and molecular and biological heterogeneity of OPMD. Finally, while treatment of OPMD may improve outcome, standard therapy has been shown to be ineffective to prevent OSCC development in patients with OPMD. In this perspective paper, several experts discuss the main challenges in oral cancer prevention, in particular the need to (i) to define an OPMD classification system by integrating new pathological and molecular characteristics, aiming (ii) to better identify OPMD at high risk of malignant transformation, and (iii) to develop treatment strategies to eradicate OPMD or prevent malignant transformation.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | diagnosis, oral cancer, oral potentially malignant disorders, oral preneoplasia, prevention |
| Divisions: | Faculty of Health and Life Sciences Faculty of Health and Life Sciences > Institute of Systems, Molecular and Integrative Biology |
| Depositing User: | Symplectic Admin |
| Date Deposited: | 25 May 2022 09:09 |
| Last Modified: | 18 Jan 2023 21:01 |
| DOI: | 10.3390/cancers14071815 |
| Open Access URL: | https://doi.org/10.3390/cancers14071815 |
| Related URLs: | |
| URI: | https://livrepository.liverpool.ac.uk/id/eprint/3155455 |
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