Davison, Helen R 
ORCID: 0000-0002-4302-5756, Pilgrim, Jack, Wybouw, Nicky, Parker, Joseph, Pirro, Stacy, Hunter-Barnett, Simon, Campbell, Paul M, Blow, Frances, Darby, Alistair C ORCID: 0000-0002-3786-6209, Hurst, Gregory DD ORCID: 0000-0002-7163-7784 et al (show 1 more authors)
(2022)
Genomic diversity across the Rickettsia and 'Candidatus Megaira' genera and proposal of genus status for the Torix group.
NATURE COMMUNICATIONS, 13 (1).
2630-.
Abstract
Members of the bacterial genus Rickettsia were originally identified as causative agents of vector-borne diseases in mammals. However, many Rickettsia species are arthropod symbionts and close relatives of 'Candidatus Megaira', which are symbiotic associates of microeukaryotes. Here, we clarify the evolutionary relationships between these organisms by assembling 26 genomes of Rickettsia species from understudied groups, including the Torix group, and two genomes of 'Ca. Megaira' from various insects and microeukaryotes. Our analyses of the new genomes, in comparison with previously described ones, indicate that the accessory genome diversity and broad host range of Torix Rickettsia are comparable to those of all other Rickettsia combined. Therefore, the Torix clade may play unrecognized roles in invertebrate biology and physiology. We argue this clade should be given its own genus status, for which we propose the name 'Candidatus Tisiphia'.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | Animals, Mammals, Arthropods, Rickettsia, Genomics, Phylogeny, Symbiosis |
| Divisions: | Faculty of Health and Life Sciences Faculty of Health and Life Sciences > Institute of Infection, Veterinary and Ecological Sciences |
| Depositing User: | Symplectic Admin |
| Date Deposited: | 06 Jun 2022 08:47 |
| Last Modified: | 18 Jan 2023 21:00 |
| DOI: | 10.1038/s41467-022-30385-6 |
| Open Access URL: | https://www.nature.com/articles/s41467-022-30385-6 |
| Related URLs: | |
| URI: | https://livrepository.liverpool.ac.uk/id/eprint/3155805 |
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