Trobisch, Andreas, Schweintzger, Nina A, Kohlfurst, Daniela S, Sagmeister, Manfred G, Sperl, Matthias, Grisold, Andrea J, Feierl, Gebhard, Herberg, Jethro A, Carrol, Enitan D 
ORCID: 0000-0001-8357-7726, Paulus, Stephane C et al (show 16 more authors)
(2022)
Osteoarticular Infections in Pediatric Hospitals in Europe: A Prospective Cohort Study From the EUCLIDS Consortium.
FRONTIERS IN PEDIATRICS, 10.
744182-.
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Osteoarticular Infections in Pediatric Hospitals in Europe A Prospective Cohort Study From the EUCLIDS Consortium.pdf - Published version Download (4MB) | Preview |
Abstract
<h4>Background</h4>Pediatric osteoarticular infections (POAIs) are serious diseases requiring early diagnosis and treatment.<h4>Methods</h4>In this prospective multicenter cohort study, children with POAIs were selected from the European Union Childhood Life-threatening Infectious Diseases Study (EUCLIDS) database to analyze their demographic, clinical, and microbiological data.<h4>Results</h4>A cohort of 380 patients with POAIs, 203 with osteomyelitis (OM), 158 with septic arthritis (SA), and 19 with both OM and SA, was analyzed. Thirty-five patients were admitted to the Pediatric Intensive Care Unit; out of these, six suffered from shock, one needed an amputation of the right foot and of four left toes, and two had skin transplantation. According to the Pediatric Overall Performance Score, 36 (10.5%) showed a mild overall disability, 3 (0.8%) a moderate, and 1 (0.2%) a severe overall disability at discharge. A causative organism was detected in 65% (247/380) of patients. <i>Staphylococcus aureus</i> (<i>S. aureus</i>) was identified in 57.1% (141/247) of microbiological confirmed cases, including 1 (0.7%) methicillin-resistant <i>S. aureus</i> (MRSA) and 6 (4.2%) Panton-Valentine leukocidin (PVL)-producing <i>S. aureus</i>, followed by Group A <i>Streptococcus</i> (18.2%) and <i>Kingella kingae</i> (8.9%). <i>K. kingae</i> and PVL production in <i>S. aureus</i> were less frequently reported than expected from the literature.<h4>Conclusion</h4>POAIs are associated with a substantial morbidity in European children, with <i>S. aureus</i> being the major detected pathogen. In one-third of patients, no causative organism is identified. Our observations show an urgent need for the development of a vaccine against <i>S. aureus</i> and for the development of new microbiologic diagnostic guidelines for POAIs in European pediatric hospitals.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | aureus, EUCLIDS, Europe, pediatric osteomyelitis, pediatric septic arthritis, S |
| Divisions: | Faculty of Health and Life Sciences Faculty of Health and Life Sciences > Institute of Infection, Veterinary and Ecological Sciences |
| Depositing User: | Symplectic Admin |
| Date Deposited: | 06 Jun 2022 08:30 |
| Last Modified: | 18 Jan 2023 21:00 |
| DOI: | 10.3389/fped.2022.744182 |
| Related URLs: | |
| URI: | https://livrepository.liverpool.ac.uk/id/eprint/3155925 |
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