Assessment of Arterial Stiffness in Patients With Resistant Hypertension: Additional Insights Into the Pathophysiology of This Condition?

Alsharari, Reem, Lip, Gregory YH ORCID: 0000-0002-7566-1626 and Shantsila, Alena ORCID: 0000-0002-0594-8576 (2020) Assessment of Arterial Stiffness in Patients With Resistant Hypertension: Additional Insights Into the Pathophysiology of This Condition? AMERICAN JOURNAL OF HYPERTENSION, 33 (2). pp. 107-115.

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Abstract

<h4>Background</h4>Good understanding of the pathophysiological mechanism(s) of resistant hypertension (RH) and the relationship to vascular dysfunction is important for optimal blood pressure control.<h4>Methods and results</h4>The aim of this review article is to summarize the available data on the methods of arterial stiffness assessment, and their usefulness in RH. Several studies that provide information on the noninvasive methods of evaluation of arterial stiffness have been discussed; specifically, pulse wave velocity (PWV) and augmentation index (AIx) tests. Increased arterial stiffness, elevated AIx, and impaired endothelial function all act as indicators and predictors of cardiovascular events in patients with hypertension (HTN).<h4>Conclusion</h4>Our review suggests that PWV and AIx are impaired in patients with severe HTN. Early assessment of these characteristics can potentially be of value in patients with RH.

Item Type:	Article
Uncontrolled Keywords:	arterial stiffness, augmentation index, blood pressure, high blood pressure, hypertension, pulse wave velocity, resistant hypertension, vascular function, vascular remodeling
Divisions:	Faculty of Health and Life Sciences Faculty of Health and Life Sciences > Institute of Life Courses and Medical Sciences
Depositing User:	Symplectic Admin
Date Deposited:	20 Jun 2022 14:23
Last Modified:	18 Jan 2023 20:57
DOI:	10.1093/ajh/hpz169
Related URLs:	Author Publisher
URI:	https://livrepository.liverpool.ac.uk/id/eprint/3156680