The changing landscape for the management of patients with neovascular AMD: brolucizumab in clinical practice



Pearce, Ian, Amoaku, Winfried, Bailey, Clare, Downey, Louise, Gale, Richard, Ghanchi, Faruque, Hamilton, Robin, Mahmood, Sajjad, Menon, Geeta, Nosek, Jenny
et al (show 2 more authors) (2022) The changing landscape for the management of patients with neovascular AMD: brolucizumab in clinical practice. EYE, 36 (9). pp. 1725-1734.

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Abstract

Untreated neovascular age-related macular degeneration (nAMD) can lead to severe and permanent visual impairment. The chronic nature of the disease can have a significant impact on patients' quality of life and an economic and time burden on medical retina (MR) services, with the care need outweighing the growth of resources that clinical services can access. The introduction of a new treatment into clinical services can be challenging, especially for services that are already under capacity constraints. Guidance for practical implementation is therefore helpful. Roundtable meetings, facilitated by Novartis UK, between a working group of MR experts with experience of leading and managing NHS retinal services in the intravitreal era were conducted between 2020 and 2021. These meetings explored various aspects and challenges of introducing a new anti-vascular endothelial growth factor (VEGF) therapy to the UK medical retina services. Provision of clear expert recommendations and practical guidance nationally, that can be adapted locally as required to support clinicians and healthcare professionals (HCPs), is valuable in supporting the introduction of a new anti-VEGF therapy within the NHS environment. The experts provide ophthalmologic HCPs with a collation of insights and recommendations to support the introduction and delivery of brolucizumab in their local service in the face of current and projected growth in demand for retina care.

Item Type: Article
Uncontrolled Keywords: Humans, Angiogenesis Inhibitors, Vascular Endothelial Growth Factor A, Visual Acuity, Quality of Life, Wet Macular Degeneration, Intravitreal Injections, Antibodies, Monoclonal, Humanized
Divisions: Faculty of Health and Life Sciences
Faculty of Health and Life Sciences > Institute of Life Courses and Medical Sciences
Depositing User: Symplectic Admin
Date Deposited: 21 Jun 2022 09:44
Last Modified: 18 Jan 2023 20:57
DOI: 10.1038/s41433-022-02008-3
Open Access URL: https://doi.org/10.1038/s41433-022-02008-3
Related URLs:
URI: https://livrepository.liverpool.ac.uk/id/eprint/3156885