Shakil, Anika, Hern, Faye Y, Liu, Chung, Temburnikar, Kartik, Chambon, Pierre, Liptrott, Neill 
ORCID: 0000-0002-5980-8966, McDonald, Tom O ORCID: 0000-0002-9273-9173, Neary, Megan ORCID: 0000-0002-4960-2139, Owen, Andrew ORCID: 0000-0002-9819-7651, Freel Meyers, Caren et al (show 1 more authors)
(2022)
Linear and branched polymer prodrugs of the water-soluble nucleoside reverse-transcriptase inhibitor emtricitabine as structural materials for long-acting implants.
JOURNAL OF MATERIALS CHEMISTRY B, 10 (23).
pp. 4395-4404.
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Linear and branched polymer prodrugs of the water-soluble nucleoside reverse-transcriptase inhibitor emtricitabine as structural materials for long-acting implants, A. Shakil, F. Y. Hern, C. Liu, K. Temburn.pdf - Published version Download (3MB) | Preview |
Abstract
Long-acting drug delivery is a growing area of interest as it overcomes many challenges related to patient adherence to therapy and the pill burden associated with chronic illness. Injectable formulations are becoming more common and drug-releasing implants also provide several opportunities. Highly water soluble drug compounds are poor candidates for long-acting delivery. Here, the water-soluble nucleoside reverse transcriptase inhibitor emtricitabine (FTC) has been used as a novel A-B monomer in step-growth polymerisation with chloroformate functional C<sub><i>n</i></sub> monomers, to produce new poly(carbamate/carbonate) structures with varying architecture. The polymer prodrugs were all solid at ambient temperature and have been shown to release FTC when subjected to mixed gender human plasma. Vacuum compression moulding has been used to form solid rod implants without polymer degradation; the rods show FTC release over long periods in the presence of microsomes, establishing the basis of a polymer prodrug strategy for FTC delivery.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | Humans, HIV Infections, Water, Polymers, DNA-Directed RNA Polymerases, Nucleosides, Prodrugs, Reverse Transcriptase Inhibitors, Anti-HIV Agents, Emtricitabine |
| Divisions: | Faculty of Health and Life Sciences Faculty of Health and Life Sciences > Institute of Systems, Molecular and Integrative Biology Faculty of Science and Engineering > School of Physical Sciences |
| Depositing User: | Symplectic Admin |
| Date Deposited: | 11 Jul 2022 14:10 |
| Last Modified: | 18 Jan 2023 20:56 |
| DOI: | 10.1039/d2tb00825d |
| Related URLs: | |
| URI: | https://livrepository.liverpool.ac.uk/id/eprint/3158056 |
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