The aetiopathogenesis of vaccine-induced immune thrombotic thrombocytopenia

Toh, Cheng-Hock, Wang, Guozheng ORCID: 0000-0001-5525-3548 and Parker, Alan L (2022) The aetiopathogenesis of vaccine-induced immune thrombotic thrombocytopenia. CLINICAL MEDICINE, 22 (2). pp. 140-144.

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Official URL: http://dx.doi.org/10.7861/clinmed.2022-0006

Abstract

In the new science emanating from the COVID-19 pandemic, effective vaccine development has made a huge difference and saved countless lives. Vaccine roll-out led to the identification of rare cases of severe thrombotic and thrombocytopenic problems in some recipients. This apparent coupling of thrombosis with haemorrhagic potentiation might seem baffling but the ensuing clinical investigation rapidly shed important light on its molecular mechanism. This review outlines the current understanding on the role of adenovirus-based platforms, the immunogenic triggers and the immunothrombotic response underlying vaccine-induced immune thrombotic thrombocytopenia.

Item Type:	Article
Uncontrolled Keywords:	adenovirus vaccines, COVID-19, Fc-gamma-RIIa, platelet factor-4, vaccine-induced immune thrombotic thrombocytopenia
Divisions:	Faculty of Health and Life Sciences Faculty of Health and Life Sciences > Institute of Infection, Veterinary and Ecological Sciences
Depositing User:	Symplectic Admin
Date Deposited:	11 Jul 2022 15:26
Last Modified:	25 Dec 2023 04:08
DOI:	10.7861/clinmed.2022-0006
Open Access URL:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC89668...
Related URLs:	Author Publisher
URI:	https://livrepository.liverpool.ac.uk/id/eprint/3158182