Age-associated differences in the cancer molecular landscape.

Chatsirisupachai, Kasit ORCID: 0000-0001-9446-6714, Lagger, Cyril ORCID: 0000-0003-1701-6896 and de Magalhães, João Pedro (2022) Age-associated differences in the cancer molecular landscape. Trends in cancer, 8 (11). pp. 962-971.

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Official URL: http://dx.doi.org/10.1016/j.trecan.2022.06.007

Abstract

Cancer is an age-related disease, as incidence and mortality for most types of cancer increase with age. However, how molecular alterations in tumors differ among patients of different ages remains poorly understood. Recent studies have shed light on the age-associated molecular landscapes in cancer. Here, we summarize the main findings of these current studies, highlighting major differences in the genomic, transcriptomic, epigenetic, and immunological landscapes between cancer in younger and older patients. Importantly, some cancer driver genes are mutated more frequently in younger or older patients. We discuss the potential roles of aging-related processes in shaping these age-related differences in cancer. We further emphasize the remaining unsolved questions that could provide important insights that will have implications in personalized medicine.

Item Type:	Article
Uncontrolled Keywords:	Humans, Neoplasms, Genomics, Transcriptome, Precision Medicine
Divisions:	Faculty of Health and Life Sciences
Depositing User:	Symplectic Admin
Date Deposited:	12 Jul 2022 15:48
Last Modified:	18 Jan 2023 20:56
DOI:	10.1016/j.trecan.2022.06.007
Open Access URL:	https://doi.org/10.1016/j.trecan.2022.06.007
Related URLs:	Author Publisher
URI:	https://livrepository.liverpool.ac.uk/id/eprint/3158313