<i>In vitro</i> susceptibility of <i>Mycoplasma iowae</i> isolates to antimicrobial agents



Buni, Dominika, Udvari, Lilla, Foldi, Dorottya, Belecz, Nikolett, Yvon, Cecile, Bradbury, Janet ORCID: 0000-0003-2416-220X, Catania, Salvatore, Lysnyansky, Inna, Kovacs, Laszlo, Gyuranecz, Miklos
et al (show 1 more authors) (2022) <i>In vitro</i> susceptibility of <i>Mycoplasma iowae</i> isolates to antimicrobial agents. AVIAN PATHOLOGY, 51 (4). pp. 374-380.

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Abstract

<b>ABSTRACT</b><i>Mycoplasma iowae,</i> a potential re-emerging avian pathogen mainly affecting turkeys, has been reported from many parts of the world. Poor hatchability, embryonic death, joint and skeletal abnormalities, poor ossification, runting-stunting, poor feathering and airsacculitis may be observed in infected flocks. The reduction of the severity of clinical signs and short-term control of <i>M. iowae</i> are performed by antibiotic treatment. However, <i>M. iowae</i> develops resistance more rapidly and is considered to be more resistant to antimicrobials than other avian pathogenic mycoplasmas. The aim of the present study was to determine the <i>in vitro</i> susceptibility of 101 <i>M. iowae</i> isolates and strains to ten clinically important antimicrobial agents, and to analyse and compare the susceptibility patterns of isolates of various origins and from a wide time-period. The examined reference strains showed high susceptibility to all antimicrobials except for spectinomycin. Low concentrations of tiamulin, florfenicol and oxytetracycline inhibited the growth of the clinical isolates. Nevertheless, slow tendency of increasing minimum inhibitory concentration (MIC) values was observed over time in the case of the above mentioned agents, while MIC values of enrofloxacin showed relatively rapid changes. Spiramycin, erythromycin, tilmicosin, tylosin, lincomycin and spectinomycin did not inhibit the bacterial growth in most of the cases. Isolates originating from captive game birds showed similar susceptibility profiles to isolates from industrial turkey hosts. The widely detected low susceptibility of <i>M. iowae</i> isolates to macrolides, lincomycin and spectinomycin, and the increase of MIC values of frequently used antimicrobials against this pathogen, emphasize the importance of targeted antibiotic therapy.RESEARCH HIGHLIGHTSAntimicrobial susceptibilities of 101 <i>Mycoplasma iowae</i> isolates were determined.Minimum inhibitory concentrations were determined by broth micro-dilution method.Tiamulin, oxytetracycline and florfenicol showed low MIC values.Isolates rapidly adapted to antimicrobial pressure.

Item Type: Article
Uncontrolled Keywords: Antibiotic susceptibility, broth micro-dilution, game bird, MIC, Mycoplasma iowae, turkey
Divisions: Faculty of Health and Life Sciences
Faculty of Health and Life Sciences > Institute of Infection, Veterinary and Ecological Sciences
Depositing User: Symplectic Admin
Date Deposited: 14 Jul 2022 14:30
Last Modified: 21 Oct 2023 15:26
DOI: 10.1080/03079457.2022.2072271
Open Access URL: https://doi.org/10.1080/03079457.2022.2072271
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URI: https://livrepository.liverpool.ac.uk/id/eprint/3158484