Albers, Lucia, Sobotzki, Christina, Kuss, Oliver, Ajslev, Teresa, Batista, Rosangela FL, Bettiol, Heloisa, Brabin, Bernard, Buka, Stephen L, Cardoso, Viviane C, Clifton, Vicki L et al (show 20 more authors)
(2018)
Maternal smoking during pregnancy and offspring overweight: is there a dose-response relationship? An individual patient data meta-analysis.
INTERNATIONAL JOURNAL OF OBESITY, 42 (7).
pp. 1249-1264.
Abstract
<h4>Background/objectives</h4>A number of meta-analyses suggest an association between any maternal smoking in pregnancy and offspring overweight obesity. Whether there is a dose-response relationship across number of cigarettes and whether this differs by sex remains unclear.<h4>Subject/methods</h4>Studies reporting number of cigarettes smoked during pregnancy and offspring BMI published up to May 2015 were searched. An individual patient data meta-analysis of association between the number of cigarettes smoked during pregnancy and offspring overweight (defined according to the International Obesity Task Force reference) was computed using a generalized additive mixed model with non-linear effects and adjustment for confounders (maternal weight status, breastfeeding, and maternal education) and stratification for sex.<h4>Results</h4>Of 26 identified studies, 16 authors provided data on a total of 238,340 mother-child-pairs. A linear positive association was observed between the number of cigarettes smoked and offspring overweight for up to 15 cigarettes per day with an OR increase per cigarette of 1.03, 95% CI = [1.02-1.03]. The OR flattened with higher cigarette use. Associations were similar in males and females. Sensitivity analyses supported these results.<h4>Conclusions</h4>A linear dose-response relationship of maternal smoking was observed in the range of 1-15 cigarettes per day equally in boys and girls with no further risk increase for doses above 15 cigarettes.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | Humans, Prenatal Exposure Delayed Effects, Body Mass Index, Smoking, Child Development, Sex Distribution, Pregnancy, Dose-Response Relationship, Drug, Adult, Child, Child, Preschool, Infant, Infant, Newborn, Pregnant Women, Female, Male, Pediatric Obesity |
| Divisions: | Faculty of Health and Life Sciences Faculty of Health and Life Sciences > Institute of Infection, Veterinary and Ecological Sciences |
| Depositing User: | Symplectic Admin |
| Date Deposited: | 26 Jul 2022 15:26 |
| Last Modified: | 18 Jan 2023 20:55 |
| DOI: | 10.1038/s41366-018-0050-0 |
| Open Access URL: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC66852... |
| Related URLs: | |
| URI: | https://livrepository.liverpool.ac.uk/id/eprint/3159289 |
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