Structural network alterations in focal and generalized epilepsy assessed in a worldwide ENIGMA study follow axes of epilepsy risk gene expression



Larivière, Sara, Royer, Jessica, Rodríguez-Cruces, Raúl, Paquola, Casey, Caligiuri, Maria Eugenia, Gambardella, Antonio, Concha, Luis, Keller, Simon S ORCID: 0000-0001-5247-9795, Cendes, Fernando, Yasuda, Clarissa L
et al (show 64 more authors) (2022) Structural network alterations in focal and generalized epilepsy assessed in a worldwide ENIGMA study follow axes of epilepsy risk gene expression. Nature Communications, 13 (1). 4320-.

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Abstract

<jats:title>Abstract</jats:title><jats:p>Epilepsy is associated with genetic risk factors and cortico-subcortical network alterations, but associations between neurobiological mechanisms and macroscale connectomics remain unclear. This multisite ENIGMA-Epilepsy study examined whole-brain structural covariance networks in patients with epilepsy and related findings to postmortem epilepsy risk gene expression patterns. Brain network analysis included 578 adults with temporal lobe epilepsy (TLE), 288 adults with idiopathic generalized epilepsy (IGE), and 1328 healthy controls from 18 centres worldwide. Graph theoretical analysis of structural covariance networks revealed increased clustering and path length in orbitofrontal and temporal regions in TLE, suggesting a shift towards network regularization. Conversely, people with IGE showed decreased clustering and path length in fronto-temporo-parietal cortices, indicating a random network configuration. Syndrome-specific topological alterations reflected expression patterns of risk genes for hippocampal sclerosis in TLE and for generalized epilepsy in IGE. These imaging-transcriptomic signatures could potentially guide diagnosis or tailor therapeutic approaches to specific epilepsy syndromes.</jats:p>

Item Type: Article
Uncontrolled Keywords: Nerve Net, Humans, Epilepsy, Epilepsy, Temporal Lobe, Epilepsy, Generalized, Immunoglobulin E, Magnetic Resonance Imaging, Gene Expression, Adult, Connectome
Divisions: Faculty of Health and Life Sciences
Faculty of Health and Life Sciences > Institute of Systems, Molecular and Integrative Biology
Depositing User: Symplectic Admin
Date Deposited: 02 Aug 2022 07:07
Last Modified: 18 Jan 2023 20:53
DOI: 10.1038/s41467-022-31730-5
Open Access URL: https://www.nature.com/articles/s41467-022-31730-5
Related URLs:
URI: https://livrepository.liverpool.ac.uk/id/eprint/3160127