Innate Immunity Crosstalk with <i>Helicobacter pylori</i>: Pattern Recognition Receptors and Cellular Responses



Cheok, Yi Ying, Tan, Grace Min Yi, Lee, Chalystha Yie Qin, Abdullah, Suhailah, Looi, Chung Yeng and Wong, Won Fen
(2022) Innate Immunity Crosstalk with <i>Helicobacter pylori</i>: Pattern Recognition Receptors and Cellular Responses. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 23 (14). 7561-.

[img] Text
Innate Immunity Crosstalk with iHelicobacter pylorii Pattern Recognition Receptors and Cellular Responses.pdf - Published version

Download (936kB) | Preview

Abstract

<i>Helicobacter pylori</i> is one of the most successful gastric pathogens that has co-existed with human for centuries. <i>H. pylori</i> is recognized by the host immune system through human pattern recognition receptors (PRRs), such as toll-like receptors (TLRs), C-type lectin like receptors (CLRs), NOD-like receptors (NLRs), and RIG-I-like receptors (RLRs), which activate downstream signaling pathways. Following bacterial recognition, the first responders of the innate immune system, including neutrophils, macrophages, and dendritic cells, eradicate the bacteria through phagocytic and inflammatory reaction. This review provides current understanding of the interaction between the innate arm of host immunity and <i>H. pylori</i>, by summarizing <i>H. pylori</i> recognition by PRRs, and the subsequent signaling pathway activation in host innate immune cells.

Item Type: Article
Uncontrolled Keywords: Helicobacter pylori, innate immune activation, pattern recognition receptors, TLRs, CLRs, NLRs, RLRs, macrophages
Divisions: Faculty of Health and Life Sciences
Faculty of Health and Life Sciences > Institute of Systems, Molecular and Integrative Biology
Depositing User: Symplectic Admin
Date Deposited: 08 Aug 2022 14:41
Last Modified: 14 Oct 2023 13:33
DOI: 10.3390/ijms23147561
Related URLs:
URI: https://livrepository.liverpool.ac.uk/id/eprint/3160717