COVID-19 outcomes in haematopoietic cell transplant recipients: A systematic review and meta-analysis.

Lim, Yeong Jer ORCID: 0000-0002-9022-2904, Khan, Umair, Karpha, Indrani, Ross, Andrew, Saif, Muhammad, Remberger, Mats, Kalakonda, Nagesh, Pettitt, Andrew R and Floisand, Yngvar (2022) COVID-19 outcomes in haematopoietic cell transplant recipients: A systematic review and meta-analysis. EJHaem, 3 (3). pp. 862-872.

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Official URL: http://dx.doi.org/10.1002/jha2.465

Abstract

Up-to-date information on coronavirus disease 2019 (COVID-19) outcomes and risk factors in haematopoietic cell transplantation (HCT) recipients is required to inform on decisions about cancer treatment and COVID-19 mitigation strategies. We performed a meta-analysis to address this knowledge gap. All studies with at least five patients who reported COVID-19-related deaths in HCT recipients were included. The primary outcome was COVID-19-related death. Secondary outcomes were COVID-19-related mechanical ventilation (MV) and intensive care unit (ITU) admission. The cumulative COVID-19-related death rate among HCT recipients was 21% (95% confidence interval [CI] 18%-24%), while MV and ITU admission rates were 14% (95% CI 11%-17%) and 18% (95% CI 14%-22%), respectively. Subgroup analysis showed higher death rates in patients who developed COVID-19 within 12 months of HCT (risk ratio [RR] 1.82, 95% CI 1.09-3.03), within 6 months of receiving immunosuppressant drugs (RR 2.11, 95% CI 1.38-3.20) or in the context of active graft-versus-host disease (RR 2.38, 95% CI 1.10-5.16). Our findings support the idea that HCT should remain an integral part of cancer treatment during the COVID-19 pandemic but also highlight the need to prioritise preventative measures in those patients who are at increased risk of adverse COVID-19 outcomes.

Item Type:	Article
Additional Information:	Source info: THELANCET-D-22-00089
Uncontrolled Keywords:	COVID‐19, SCT, stem cell transplantation
Divisions:	Faculty of Health and Life Sciences Faculty of Health and Life Sciences > Clinical Directorate Faculty of Health and Life Sciences > Institute of Systems, Molecular and Integrative Biology
Depositing User:	Symplectic Admin
Date Deposited:	22 Aug 2022 07:41
Last Modified:	18 Jan 2023 20:47
DOI:	10.1002/jha2.465
Related URLs:	Author Publisher
URI:	https://livrepository.liverpool.ac.uk/id/eprint/3161887