Endothelial failure and rejection in recipients of corneas from the same donor



Downward, Lewis, Ahmed, Mahmoud, Hopkinson, Cathy, Romano, Vito, Curnow, Elinor and Kaye, Stephen B ORCID: 0000-0003-0390-0592
(2022) Endothelial failure and rejection in recipients of corneas from the same donor. BMJ Open Ophthalmology, 7 (1). e000965-e000965.

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Abstract

<jats:sec><jats:title>Objective</jats:title><jats:p>To determine whether patients who receive corneas from the same donor have similar risks of endothelial failure and rejection.</jats:p></jats:sec><jats:sec><jats:title>Methods and Analysis</jats:title><jats:p>Patients with Fuchs endothelial dystrophy (FED) and pseudophakic bullous keratopathy (PBK) who received their first corneal transplant between 1999 and 2016 were analysed. Patients receiving corneas from donors who donated both corneas for the same indication were defined as ‘paired’. Gray’s test was used to compare the cumulative incidence of endothelial failure and rejection within 5 years post-transplant for ‘paired’ and ‘unpaired’ groups. Cox regression models were fitted to determine whether there was an association between recorded donor characteristics (endothelial cell density (ECD), age and sex and endothelial graft failure and rejection.</jats:p></jats:sec><jats:sec><jats:title>Results</jats:title><jats:p>10 838 patients were analysed of whom 1536 (14%) were paired. The unpaired group comprised 1837 (69%) recipients of single corneal donors and 7465 (69%) donors who donated both corneas for another indication. ECD was lower for unpaired single cornea donors (p&lt;0.01). There was no significant difference in endothelial graft failure or rejection between paired and unpaired groups for FED (p=0.37, p=0.99) or PBK (p=0.88, p=0.28) nor for donor ECD, age, sex and paired donation after adjusting for transplant factors (across all models p&gt;0.16 for ECD, p&gt;0.32 for donor age, p&gt;0.14 for sex match and p&gt;0.17 for the donor effect).</jats:p></jats:sec><jats:sec><jats:title>Conclusion</jats:title><jats:p>The absence of a significant difference in graft outcome for corneal transplants for FED and PBK between paired and unpaired donors may reflect a homogeneous donor pool in the UK.</jats:p></jats:sec>

Item Type: Article
Uncontrolled Keywords: Cornea, Humans, Fuchs' Endothelial Dystrophy, Corneal Edema, Corneal Transplantation, Graft Survival, Tissue Donors
Divisions: Faculty of Health and Life Sciences
Faculty of Health and Life Sciences > Institute of Life Courses and Medical Sciences
Depositing User: Symplectic Admin
Date Deposited: 23 Aug 2022 07:48
Last Modified: 18 Jan 2023 20:47
DOI: 10.1136/bmjophth-2021-000965
Open Access URL: http://10.0.4.112/bmjophth-2021-000965
Related URLs:
URI: https://livrepository.liverpool.ac.uk/id/eprint/3162060