Off-the-Shelf Gd(NO<sub>3</sub>)<sub>3</sub> as an Efficient High-Spin Metal Ion Polarizing Agent for Magic Angle Spinning Dynamic Nuclear Polarization


Elliott, Stuart J, Duff, Benjamin B ORCID: 0000-0002-7398-5002, Taylor-Hughes, Ashlea R, Cheney, Daniel J, Corley, John P, Paul, Subhradip, Brookfield, Adam, Pawsey, Shane, Gajan, David, Aspinall, Helen C et al (show 2 more authors) (2022) Off-the-Shelf Gd(NO<sub>3</sub>)<sub>3</sub> as an Efficient High-Spin Metal Ion Polarizing Agent for Magic Angle Spinning Dynamic Nuclear Polarization. JOURNAL OF PHYSICAL CHEMISTRY B, 126 (33). pp. 6281-6289.

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Abstract

Magic angle spinning nuclear magnetic resonance spectroscopy experiments are widely employed in the characterization of solid media. The approach is incredibly versatile but deleteriously suffers from low sensitivity, which may be alleviated by adopting dynamic nuclear polarization methods, resulting in large signal enhancements. Paramagnetic metal ions such as Gd<sup>3+</sup> have recently shown promising results as polarizing agents for <sup>1</sup>H, <sup>13</sup>C, and <sup>15</sup>N nuclear spins. We demonstrate that the widely available and inexpensive chemical agent Gd(NO<sub>3</sub>)<sub>3</sub> achieves significant signal enhancements for the <sup>13</sup>C and <sup>15</sup>N nuclear sites of [2-<sup>13</sup>C,<sup>15</sup>N]glycine at 9.4 T and ∼105 K. Analysis of the signal enhancement profiles at two magnetic fields, in conjunction with electron paramagnetic resonance data, reveals the solid effect to be the dominant signal enhancement mechanism. The signal amplification obtained paves the way for efficient dynamic nuclear polarization without the need for challenging synthesis of Gd<sup>3+</sup> polarizing agents.

Item Type: Article
Uncontrolled Keywords: Ions, Metals, Magnetic Resonance Spectroscopy, Electron Spin Resonance Spectroscopy, Magnetic Fields
Divisions: Faculty of Science and Engineering > School of Physical Sciences
Depositing User: Symplectic Admin
Date Deposited: 31 Aug 2022 14:45
Last Modified: 05 Oct 2023 21:53
DOI: 10.1021/acs.jpcb.2c04184
Related URLs:
URI: https://livrepository.liverpool.ac.uk/id/eprint/3162962
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