Hepatitis B Viral Protein HBx and the Molecular Mechanisms Modulating the Hallmarks of Hepatocellular Carcinoma: A Comprehensive Review

Sivasudhan, Enakshi, Blake, Neil, Lu, Zhiliang ORCID: 0000-0002-3442-1415, Meng, Jia ORCID: 0000-0003-3455-205X and Rong, Rong (2022) Hepatitis B Viral Protein HBx and the Molecular Mechanisms Modulating the Hallmarks of Hepatocellular Carcinoma: A Comprehensive Review. CELLS, 11 (4). 741-.

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Abstract

With 296 million cases estimated worldwide, chronic hepatitis B virus (HBV) infection is the most common risk factor for hepatocellular carcinoma (HCC). HBV-encoded oncogene X protein (HBx), a key multifunctional regulatory protein, drives viral replication and interferes with several cellular signalling pathways that drive virus-associated hepatocarcinogenesis. This review article provides a comprehensive overview of the role of HBx in modulating the various hallmarks of HCC by supporting tumour initiation, progression, invasion and metastasis. Understanding HBx-mediated dimensions of complexity in driving liver malignancies could provide the key to unlocking novel and repurposed combinatorial therapies to combat HCC.

Item Type:	Article
Uncontrolled Keywords:	cancer hallmarks, HBx protein, hepatitis B virus, hepatocellular carcinoma, therapeutics
Divisions:	Faculty of Health and Life Sciences Faculty of Health and Life Sciences > Institute of Infection, Veterinary and Ecological Sciences Faculty of Science and Engineering > School of Electrical Engineering, Electronics and Computer Science
Depositing User:	Symplectic Admin
Date Deposited:	09 Sep 2022 10:00
Last Modified:	18 Jan 2023 20:45
DOI:	10.3390/cells11040741
Open Access URL:	https://doi.org/10.3390/cells11040741
Related URLs:	Author Publisher
URI:	https://livrepository.liverpool.ac.uk/id/eprint/3163999

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• Hepatitis B Viral Protein HBx and the Molecular Mechanisms Modulating the Hallmarks of Hepatocellular Carcinoma: A Comprehensive Review. (deposited 10 May 2022 07:50)
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