Jing, Changcheng, Jones, Benjamin T, Adams, Ross J and Bower, John F 
ORCID: 0000-0002-7551-8221
(2022)
Cyclopropane-Fused N-Heterocycles via Aza-Heck-Triggered C(sp<SUP>3</SUP>)-H Functionalization Cascades.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 144 (37).
pp. 16749-16754.
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Abstract
Unique examples of aza-Heck-based C(sp<sup>3</sup>)-H functionalization cascades are described. Under Pd(0)-catalyzed conditions, the aza-Heck-type cyclization of <i>N</i>-(pentafluorobenzoyloxy)carbamates generates alkyl-Pd(II) intermediates that effect C(sp<sup>3</sup>)-H palladation en route to cyclopropanes. Key factors that control the site selectivity of the cyclopropanation process have been elucidated such that selective access to a wide range of ring- or spiro-fused systems can be achieved.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | Carbamates, Cyclopropanes, Cyclization, Catalysis |
| Divisions: | Faculty of Science and Engineering > School of Physical Sciences |
| Depositing User: | Symplectic Admin |
| Date Deposited: | 27 Sep 2022 08:58 |
| Last Modified: | 18 Oct 2023 01:26 |
| DOI: | 10.1021/jacs.2c08304 |
| Related URLs: | |
| URI: | https://livrepository.liverpool.ac.uk/id/eprint/3164887 |
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