Trautenberg, Laura Christin, Brankatschk, Marko, Shevchenko, Andrej, Wigby, Stuart 
ORCID: 0000-0002-2260-2948 and Reinhardt, Klaus
(2022)
Ecological lipidology.
ELIFE, 11.
e79288-.
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elife-79288-v1.pdf - Published version Download (4MB) | Preview |
Abstract
Dietary lipids (DLs), particularly sterols and fatty acids, are precursors for endogenous lipids that, unusually for macronutrients, shape cellular and organismal function long after ingestion. These functions - cell membrane structure, intracellular signalling, and hormonal activity - vary with the identity of DLs, and scale up to influence health, survival, and reproductive fitness, thereby affecting evolutionary change. Our Ecological Lipidology approach integrates biochemical mechanisms and molecular cell biology into evolution and nutritional ecology. It exposes our need to understand environmental impacts on lipidomes, the lipid specificity of cell functions, and predicts the evolution of lipid-based diet choices. Broad interdisciplinary implications of Ecological Lipidology include food web alterations, species responses to environmental change, as well as sex differences and lifestyle impacts on human nutrition, and opportunities for DL-based therapies.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | diet choice, fatty acids, fitness, food web, membrane, sterols |
| Divisions: | Faculty of Health and Life Sciences Faculty of Health and Life Sciences > Institute of Infection, Veterinary and Ecological Sciences |
| Depositing User: | Symplectic Admin |
| Date Deposited: | 27 Sep 2022 10:04 |
| Last Modified: | 18 Jan 2023 20:41 |
| DOI: | 10.7554/eLife.79288 |
| Related URLs: | |
| URI: | https://livrepository.liverpool.ac.uk/id/eprint/3164976 |
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