Omics tools enabling vaccine discovery against fasciolosis

Cwiklinski, Krystyna ORCID: 0000-0001-5577-2735 and Dalton, John P (2022) Omics tools enabling vaccine discovery against fasciolosis. TRENDS IN PARASITOLOGY, 38 (12). pp. 1068-1079.

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Official URL: http://dx.doi.org/10.1016/j.pt.2022.09.009

Abstract

In the past decade significant advances in our understanding of liver fluke biology have been made through in-depth interrogation and analysis of evolving Fasciola hepatica and Fasciola gigantica omics datasets. This information is crucial for developing novel control strategies, particularly vaccines necessitated by the global spread of anthelmintic resistance. Distilling them down to a manageable number of testable vaccines requires combined rational, empirical, and collaborative approaches. Despite a lack of clear outstanding vaccine candidate(s), we must continue to identify salient parasite-host interacting molecules, likely in the secretory products, tegument, or extracellular vesicles, and perform robust trials especially in livestock, using present and emerging vaccinology technologies to discover that elusive liver fluke vaccine. Omics tools are bringing this prospect ever closer.

Item Type:	Article
Uncontrolled Keywords:	Animals, Fasciola, Fasciola hepatica, Fascioliasis, Vaccines, Anthelmintics
Divisions:	Faculty of Health and Life Sciences Faculty of Health and Life Sciences > Institute of Infection, Veterinary and Ecological Sciences
Depositing User:	Symplectic Admin
Date Deposited:	10 Oct 2022 08:53
Last Modified:	17 Mar 2023 11:20
DOI:	10.1016/j.pt.2022.09.009
Related URLs:	Author Publisher
URI:	https://livrepository.liverpool.ac.uk/id/eprint/3165230