Microvascular Dysfunction in Heart Failure with Preserved Ejection Fraction: Pathophysiology, Assessment, Prevalence and Prognosis.



Bilak, Joanna M, Alam, Uazman ORCID: 0000-0002-3190-1122, Miller, Christopher A ORCID: 0000-0002-5957-7088, McCann, Gerry P ORCID: 0000-0002-5542-8448, Arnold, Jayanth R ORCID: 0000-0003-4533-8374 and Kanagala, Prathap ORCID: 0000-0001-6739-5607
(2022) Microvascular Dysfunction in Heart Failure with Preserved Ejection Fraction: Pathophysiology, Assessment, Prevalence and Prognosis. Cardiac failure review, 8. e24-.

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Abstract

Heart failure with preserved ejection fraction (HFpEF) currently accounts for approximately half of all new heart failure cases in the community. HFpEF is closely associated with chronic lifestyle-related diseases, such as obesity and type 2 diabetes, and clinical outcomes are worse in those with than without comorbidities. HFpEF is pathophysiologically distinct from heart failure with reduced ejection fraction, which may explain, in part, the disparity of treatment options available between the two heart failure phenotypes. The mechanisms underlying HFpEF are complex, with coronary microvascular dysfunction (MVD) being proposed as a potential key driver in its pathophysiology. In this review, the authors highlight the evidence implicating MVD in HFpEF pathophysiology, the diagnostic approaches for identifying MVD (both invasive and non-invasive) and the prevalence and prognostic significance of MVD.

Item Type: Article
Uncontrolled Keywords: Heart failure with preserved ejection fraction, cardiovascular MRI, diagnosis, fibrosis, microvascular dysfunction, prevalence, prognosis
Divisions: Faculty of Health and Life Sciences
Faculty of Health and Life Sciences > Institute of Life Courses and Medical Sciences
Faculty of Health and Life Sciences > Clinical Directorate
Depositing User: Symplectic Admin
Date Deposited: 10 Oct 2022 08:03
Last Modified: 18 Jan 2023 20:37
DOI: 10.15420/cfr.2022.12
Related URLs:
URI: https://livrepository.liverpool.ac.uk/id/eprint/3165288