Prevalence of amyloid blood clots in COVID-19 plasma

Pretorius, Etheresia ORCID: 0000-0002-9108-2384, Venter, Chantelle, Laubscher, Gert Jacobus, Lourens, Petrus Johannes, Steenkamp, Janami and Kell, Douglas ORCID: 0000-0001-5838-7963 (2020) Prevalence of amyloid blood clots in COVID-19 plasma. 2020.07.28.20163543-.

PDF Prevalence of amyloid blood clots in COVID-19 plasma.pdf - Unspecified Download (2MB) | Preview

Abstract

The rapid detection of COVID-19 uses genotypic testing for the presence of SARS-Cov-2 virus in nasopharyngeal swabs, but it can have a poor sensitivity. A rapid, host-based physiological test that indicated whether the individual was infected or not would be highly desirable. Coagulaopathies are a common accompaniment to COVID-19, especially micro-clots within the lungs. We show here that microclots can be detected in the native plasma of COVID-19 patient, and in particular that such clots are amyloid in nature as judged by a standard fluorogenic stain. This provides a rapid and convenient test (P<0.0001), and suggests that the early detection and prevention of such clotting could have an important role in therapy.

Item Type:	Article
Uncontrolled Keywords:	Prevention, Lung, Brain Disorders, Neurosciences, Neurodegenerative, Infectious Diseases, 3 Good Health and Well Being
Divisions:	Faculty of Health and Life Sciences Faculty of Health and Life Sciences > Institute of Systems, Molecular and Integrative Biology
Depositing User:	Symplectic Admin
Date Deposited:	12 Oct 2022 08:18
Last Modified:	15 Mar 2024 15:01
DOI:	10.1101/2020.07.28.20163543
Related URLs:	Publisher
URI:	https://livrepository.liverpool.ac.uk/id/eprint/3165397