Mon, Kristel J Yee, Zhu, Hongya, Daly, Ciaran WP, Vu, Luyen T, Smith, Norah L, Patel, Ravi, Topham, David J, Scheible, Kristin, Jambo, Kondwani 
ORCID: 0000-0002-3195-2210, Le, Minh TN et al (show 2 more authors)
(2021)
MicroRNA-29 specifies age-related differences in the CD8+T cell immune response.
CELL REPORTS, 37 (6).
109969-.
Abstract
MicroRNAs (miRNAs) have emerged as critical regulators of cell fate in the CD8+ T cell response to infection. Although there are several examples of miRNAs acting on effector CD8+ T cells after infection, it is unclear whether differential expression of one or more miRNAs in the naive state is consequential in altering their long-term trajectory. To answer this question, we examine the role of miR-29 in neonatal and adult CD8+ T cells, which express different amounts of miR-29 only prior to infection and adopt profoundly different fates after immune challenge. We find that manipulation of miR-29 expression in the naive state is sufficient for age-adjusting the phenotype and function of CD8+ T cells, including their regulatory landscapes and long-term differentiation trajectories after infection. Thus, miR-29 acts as a developmental switch by controlling the balance between a rapid effector response in neonates and the generation of long-lived memory in adults.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | CD8-Positive T-Lymphocytes, Animals, Mice, Inbred C57BL, Humans, Mice, Listeria monocytogenes, MicroRNAs, Gene Expression Profiling, Lymphocyte Activation, Age Factors, Cell Differentiation, Immunologic Memory, Gene Expression Regulation, Adolescent, Adult, Middle Aged, Male, Young Adult, Listeriosis |
| Divisions: | Faculty of Health and Life Sciences Faculty of Health and Life Sciences > Institute of Infection, Veterinary and Ecological Sciences |
| Depositing User: | Symplectic Admin |
| Date Deposited: | 14 Oct 2022 08:28 |
| Last Modified: | 18 Jan 2023 20:36 |
| DOI: | 10.1016/j.celrep.2021.109969 |
| Open Access URL: | https://doi.org/10.1016/j.celrep.2021.109969 |
| Related URLs: | |
| URI: | https://livrepository.liverpool.ac.uk/id/eprint/3165447 |
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