Lateral cystic neck masses in adults: a ten-year series and comparative analysis of diagnostic modalities

Jones, GH, Chudek, D, Davies, K, Upile, N, Kinshuck, A, Triantafyllou, A, Fleming, JC ORCID: 0000-0001-7963-1224 and Roland, NJ (2022) Lateral cystic neck masses in adults: a ten-year series and comparative analysis of diagnostic modalities. JOURNAL OF LARYNGOLOGY AND OTOLOGY, 137 (3). pp. 312-318.

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Official URL: http://dx.doi.org/10.1017/s0022215122000469

Abstract

<h4>Background</h4>In adults, the solitary lateral cystic neck mass remains a diagnostic challenge with little solid material to target for cytology and few clues on imaging modalities to suggest underlying malignancy.<h4>Method</h4>This study was a retrospective review of patients presenting with a lateral cystic neck mass to a tertiary academic head and neck centre over a 10-year period.<h4>Results</h4>A total of 25 of 157 cystic lesions were subsequently malignant on paraffin section histopathology, with the youngest patient being 42 years. In the age cohort over 40 years, 30 per cent of males and 10 per cent of females were diagnosed with malignancy. The ipsilateral palatine tonsil was the most common primary site (50 per cent). A total of 85 per cent of cases demonstrated integrated human papillomavirus infection. Age, male sex and alcohol were significant risk factors on univariate analysis. Ultrasound-guided fine needle aspiration cytology and magnetic resonance imaging represented the most accurate pre-open biopsy tests.<h4>Conclusion</h4>The authors of this study advocate for a risk-stratified, evidence-based workup in patients with solitary lateral cystic neck mass in order to optimise timely diagnosis.

Item Type:	Article
Uncontrolled Keywords:	Branchial Cleft Cyst, Branchioma, Lymphatic Metastasis, Papillomavirus Infections, Squamous Cell Carcinoma Of Head And Neck
Divisions:	Faculty of Health and Life Sciences Faculty of Health and Life Sciences > Institute of Life Courses and Medical Sciences Faculty of Health and Life Sciences > Institute of Life Courses and Medical Sciences > School of Dentistry Faculty of Health and Life Sciences > Institute of Systems, Molecular and Integrative Biology
Depositing User:	Symplectic Admin
Date Deposited:	18 Oct 2022 14:26
Last Modified:	14 Mar 2023 15:19
DOI:	10.1017/S0022215122000469
Related URLs:	Author Publisher
URI:	https://livrepository.liverpool.ac.uk/id/eprint/3165610